Abstract
The spontaneously hypertensive rat and the stroke-prone spontaneously hypertensive rat are useful models for human hypertension. In these strains hypertension is a polygenic trait, in which both autosomal and sex-linked genes can influence blood pressure1–7. Linkage studies in crosses between the stroke-prone spontaneously hypertensive rat and the normotensive control strain Wistar-Kyoto have led to the localization of two genes, BP/SP-1 and BP/SP-2, that contribute significantly to blood pressure variation in the F2 population. BP/SP-1and BP/SP-2 were assigned to rat chromosomes 10 and X, respectively. Comparison of the human and rat genetic maps indicates that BP/SP-1 could reside on human chromosome 17q in a region that also contains the angiotensin l-converting enzyme gene (ACE)8. This encodes a key enzyme of the renin-angiotensin system9, and is therefore a candidate gene in primary hypertension. A rat microsatellite marker of ACE was mapped to rat chromosome 10 within the region containing BP/SP-1.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Tanase, H. et al. Jap. Circ. J. 51, 1184–1190 (1987).
Louis, W. J. et al. Lancet i, 1035–1036 (1969).
Yen, T. T. et al. Heredity 33, 309–316 (1974).
Harrap, S. B. Hypertension 8, 572–582 (1986).
Pravenec, M. et al. J. Hypertension 7, 217–221 (1989).
Ely, D. L. & Turner, M. E. Hypertension 16, 277–281 (1990).
Lindpaintner, K., Takahashi, S. & Ganten, D. J. Hypertension 8, 763–773 (1990).
Mattei, M. G. et al. Cyto. cell. Genet. 51, 1041 (1989).
Yang, H. Y. T., Erdös, E. G. & Levin, Y. Biochim. biophys. Acta 214, 374–376 (1970).
Dannenberg, A. L. et al. Hypertension 10, 266–233 (1987).
Pickering, G. Am. J. Med. 52, 570–583 (1972).
Ward, R. in Hypertension: Pathophysiology, Diagnosis and Management (eds Laragh, J. H. & Brenner, B. M.) 81–100 (Raven, New York, 1990).
Tanase, H. et al. Jap. Circ. J. 34, 1197–1212 (1970).
Yamori, Y. & Okamoto, K. Lab. Invest. 22, 206–211 (1970).
Rapp, J. P. Hypertension 4, 459–467 (1982).
Rapp, J. P., Wang, S. M. & Dene, H. Science 243, 542–544 (1989).
Kurtz, T. W. et al. J. Clin. Invest 85, 1328–1332 (1990).
Pravnec, M. et al. Genomics 9, 466–472 (1991).
Aoki, K., Yamori, Y., Ooshima, A. & Okamoto, K. Jap. Circ. J. 36, 539–545 (1972).
Dietz, R. et al. J. Cardiovasc. Pharmac. 6, s230–s235 (1984).
Gradin, K. & Persson, B. Acta physiol. Scand. 131, 273–281 (1987).
Luft, F. C. et al. J. Cli. Sci. 74, 577–585 (1988).
Dietz, R. et al. Hypertension 4, 773–781 (1982).
Julier, C. et al. Proc. natn. Acad. Sci. U.S.A. 87, 4585–4589 (1990).
Weber, J. L. & May, P. E. Am. J. hum. Genet. 44, 388–396 (1989).
Litt, M. & Luty, J. A. Am. J. hum. Genet 44, 397–401 (1989).
Todd, J. A. et al. Nature 351, 542–546 (1991).
Cooke, N., Szpirer, C. & Levan, G. Endocrinology 119, 2451–2454 (1986).
Hillyard, A. et al. Locus Map of Mouse with Comparative Map Points of Human on Mouse (The Jackson Laboratory, Bar Harbor, 1991).
Solomon, E. & Barker, D. F. Cytogenet. Cell Genet. 51, 319–337 (1989).
Guyton, A. C. Arterial Pressure and Hypertension (Saunders, Philadelphia, 1980).
Biollaz, J. et al. Hypertension 8, 117–121 (1986).
Hall, J. E. Am. J. Physiol. 19, R960–R972 (1986).
Pravenec, M. et al. Hypertension 17, 242–246 (1991).
Pravenec, M. et al. J. Hypertension 7, 217–221 (1989).
van de Ven, C. M. J. & Boln, D. F. Pfluger's Arch. Eur. J. Physiol. 399, 74–78 (1983).
Yasue, Y. et al. Cytogenet cell. Genet. (in the press).
Lathrop, G. M. & Lalouel, J. M. Am. J. hum. Genet. 36, 460–465 (1984).
Levan, G. et al. Genomics (in the press).
Lathrop, G. M. et al. Genomics 2, 157–164 (1988).
Dixon, W. J. et al. BMDP Statistical Software Manual (University of California Press, Los Angeles, 1988).
Falconer, D. S. Introduction to Quantitative Genetics 2nd edn (Oliver and Boyd, Edinburgh, 1982).
Georges, M. et al. Cytogenet. cell. Genet 47, 127–131 (1988).
Rychlik, W. & Rhoads, R. E. Nucleic Acids Res. 17, 8543–8551 (1989).
Howard, T. E. et al. Molec. cell. Biol. 10, 4294–4302 (1990).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hilbert, P., Lindpaintner, K., Beckmann, J. et al. Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats. Nature 353, 521–529 (1991). https://doi.org/10.1038/353521a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/353521a0
This article is cited by
-
Effect of ACE, ACE2 and CYP11B2 gene polymorphisms and noise on essential hypertension among steelworkers in China: a case–control study
BMC Medical Genomics (2022)
-
Genetics of Resistant Hypertension: the Missing Heritability and Opportunities
Current Hypertension Reports (2018)
-
The stroke-prone spontaneously hypertensive rat: still a useful model for post-GWAS genetic studies?
Hypertension Research (2012)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.