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Properties of afferent nerve impulses originating from a neuroma

Abstract

Damaged nerves attempt to regenerate. The nerve membrane changes its properties, becomes spontaneously active and may be the source of pain. These impulse generators have unusual properties. They become silent after high frequency activity. This silence may partially explain the effect of counterstimulation as a pain therapy.

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Wall, P., Gutnick, M. Properties of afferent nerve impulses originating from a neuroma. Nature 248, 740–743 (1974). https://doi.org/10.1038/248740a0

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