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Pregnancy complications and the risk of asthma among Norwegians born between 1967 and 1993

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Abstract

Background: Fetal life events may affect the development of the immune and/or respiratory system and increase the risk of asthma and allergic diseases. The objective of this study was to test the hypothesis that pregnancy complications are associated with the risk of developing asthma in the offspring. Methods: The study population comprised Norwegian live births 1967–1993 (n = 1,548,429) linking the Medical Birth Registry of Norway (MBRN) (exposure variables) and the National Insurance Administration Register (NIAR) (outcome variables), which covers all Norwegians. The MBRN variables included pregnancy complications, pregnancy outcomes and diseases of the mother. The NIAR provided data on all Norwegians who had received cash benefit for treatment of asthma from 1967 to 1996 (n = 5938, 3.9/1000 persons). Results: In multiple logistic regression analysis, pregnancy complications (International Classification of Diseases (ICD)-8-codes: 630–634) were associated with the risk of asthma (odds ratio 1.82, 95% confidence interval: 1.67–1.98). This was also the case if analyses were performed in different strata according to year of birth, plurality, maternal atopy, geographical district of birth, and maternal education. Conclusions: Pregnancy complications may represent risk factors for the development of asthma in the offspring or express early signs of increased risk for developing the disease.

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References

  1. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. Lancet 1998; 351: 1225–1232.

    Google Scholar 

  2. Pearce N, Sunyer J, Cheng S, Chinn S, et al. Comparison of asthma prevalence in the ISAAC and the ECRHS. ISAAC Steering Committee and the European Community Respiratory Health Survey. International Study of Asthma and Allergies in Childhood. Eur Respir J 2000; 16: 420–426.

    Google Scholar 

  3. Sunyer J, Anto JM, Tobias A, Burney P. Generational increase of self-reported first attack of asthma in fifteen industrialized countries. Eur Commun Respir Health Study (ECRHS). Eur Respir J 1999; 14: 885–891.

    Google Scholar 

  4. Turkeltaub PC, Gergen PJ. Prevalence of upper and lower respiratory conditions in the US population by social and environmental factors: Data from the second National Health and Nutrition Examination Survey, 1976 to 1980 (NHANES II). Ann Allergy 1991; 67: 147–154.

    Google Scholar 

  5. Mannino DM, Gagnon RC, Petty TL, Lydick E. Obstructive lung disease and low lung function in adults in the United States: Data from the National Health and Nutrition Examination Survey, 1988-1994. Arch Intern Med 2000; 160: 1683–1689.

    Google Scholar 

  6. Yeatts K, Shy C, Wiley J, Music S. Statewide adolescent asthma surveillance. J Asthma 2000; 37: 425–434.

    Google Scholar 

  7. Burr ML, Butland BK, King S, Vaughan-Williams E. Changes in asthma prevalence: Two surveys 15 years apart. Arch Dis Child 1989; 64: 1452–1456.

    Google Scholar 

  8. Jarvis D, Burney P. The epidemiology of allergic diseases. Br Med J 1998; 316: 607–610.

    Google Scholar 

  9. Strachan DP. The epidemiology of childhood asthma. Allergy 1999; 54: 7–11.

    Google Scholar 

  10. Downs SH, Marks GB, Sporik R, Belosouva EG, Car NG, Peat JK. Continued increase in the prevalence of asthma and atopy. Arch Dis Child 2001; 84: 20–23.

    Google Scholar 

  11. Harris JR, Magnus P, Samuelsen SO, Tambs K. No evidence for effects of family environment on asthma. A retrospective study of Norwegian twins. Am J Respir Crit Care Med 1997; 156: 43–49.

    Google Scholar 

  12. Steffensen FH, Sorensen HT, Gillman MW, et al. Low birth weight and preterm delivery as risk factors for asthma and atopic dermatitis in young adult males. Epidemiology 2000; 11: 185–188.

    Google Scholar 

  13. Darlow BA, Horwood LJ, Mogridge N. Very low birthweight and asthma by age seven years in a national cohort. Pediatr Pulmonol 2000; 30: 291–296.

    Google Scholar 

  14. Fergusson DM, Crane J, Beasley R, Horwood LJ. Perinatal factors and atopic disease in childhood. Clin Exp Allergy 1997; 27: 1394–1401.

    Google Scholar 

  15. Martinez FD. Maternal risk factors in asthma. Ciba Found Symp 1997; 206: 233–243.

    Google Scholar 

  16. Sears M. Epidemiology of childhood asthma. Lancet 1997; 350: 1015–1020.

    Google Scholar 

  17. Björksten B. Risk factors in early childhood for the development of atopic diseases. Allergy 1994; 49: 400–407.

    Google Scholar 

  18. Strachan DP, Butland BK, Anderson HR. Incidence and prognosis of asthma and wheezing illness from early childhood to age 33 in a national British cohort. Br Med J 1996; 312: 1195–1199.

    Google Scholar 

  19. Bråbäck L, Hedberg A. Perinatal risk factors for atopic disease in conscripts. Clin Exp Allergy 1998; 28: 936–942.

    Google Scholar 

  20. Leadbitter P, Pearce N, Cheng S, et al. Relationship between fetal growth and the development of asthma and atopy in childhood. Thorax 1999; 54: 905–910.

    Google Scholar 

  21. Xu B, Jarvelin MR, Pekkanen J. Prenatal factors and occurrence of rhinitis and eczema among offspring. Allergy 1999; 54: 829–836.

    Google Scholar 

  22. Xu B, Pekkanen J, Jarvelin MR, Olsen P, Hartikainen AL. Maternal infections in pregnancy and the development of asthma among offspring. Int J Epidemiol 1999; 28: 723–727.

    Google Scholar 

  23. Stein RT, Sherrill D, Morgan WJ, et al. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet 1999; 354: 541–45.

    Google Scholar 

  24. von Mutius E, Illi S, Hirsch T, Leupold W, Keil U, Weiland SK. Frequency of infections and risk of asthma, atopy and airway hyperresponsiveness in children. Eur Respir J 1999; 14: 4–11.

    Google Scholar 

  25. Ponsonby AL, Couper D, Dwyer T, Carmichael A, Kemp A. Relationship between early life respiratory illness, family size over time, and the development of asthma and hay fever: A seven year follow up study. Thorax 1999; 54: 664–669.

    Google Scholar 

  26. Nafstad P, Magnus P, Jaakkola JJK. Pregnancy complications and childhood asthma and allergic rhinitis. J Allergy Clin Immunol 2000; 106: 867–873.

    Google Scholar 

  27. Annesi-Maesano I, Moreau D, Strachan D. In utero and perinatal complications preceding asthma. Allergy 2001; 56: 491–497.

    Google Scholar 

  28. Irgens LM. The Medical Birth Registry of Norway. Epidemiological research and surveillance throughout 30 years. Acta Obstet Gynecol Scand 2000; 79: 435–439.

    Google Scholar 

  29. Nafstad P, Samuelsen SO, Irgens LM, Bjerkedal T. Birth Weight and Hearing Impairment in Norwegians Born From 1967 to 1993. Pediatrics (in press).

  30. The Norwegian Social Insurance Scheme. Royal Ministry of Health and Social Affairs 2000. ISSN 0809-0696.

  31. Shiboski SC. Generalized additive models for current status data. Lifetime Data Anal 1998; 4: 29–50.

    Google Scholar 

  32. Newacheck PW, Halfon N. Prevalence, impact, and trends in childhood disability due to asthma. Arch Pediatr Adolesc Med 2000; 154: 287–293.

    Google Scholar 

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Nafstad, P., Samuelsen, S.O., Irgens, L.M. et al. Pregnancy complications and the risk of asthma among Norwegians born between 1967 and 1993. Eur J Epidemiol 18, 755–761 (2003). https://doi.org/10.1023/A:1025395405101

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