Chemotherapy-Induced Palmar-Plantar Erythrodysesthesia Syndrome – Recall Following Different Chemotherapy Agents

Abstract

Radiation recall is a phenomenon commonlyseen in patients receiving chemotherapytreatment who have previously been exposedto radiation. A phenomenon not clearlydescribed is that of a side effect inducedby one chemotherapy agent and laterrecalled when the patient is given adifferent chemotherapy regimen. Troxacitabine is an anti-leukemic agentwhich can be associated with palmar-plantarerythrodysesthesia syndrome (PPES). Here,we report six cases oftroxacitabine-induced PPES that was laterrecalled by various chemotherapy regimens. The recall PPES was mild to moderate andself-limiting in all cases. All of thesepatients recovered from the recall sideeffects with minimal medical intervention. We conclude that a recall phenomenonsimilar to that described afterradiotherapy might occur after certainchemotherapy agents. This phenomenonshould be considered when evaluatingtoxicity from chemotherapy, particularlywhen using new and investigationalagents.