Original articleLipid profile in different degrees of hypothyroidism and effects of levothyroxine replacement in mild thyroid failure
Section snippets
Study population
Participants were recruited from the Outpatient Clinic of the Clementino Fraga Filho University Hospital (HUCFF) and Federal University of Rio de Janeiro (UFRJ) between the years 2001 and 2006. To be enrolled in the SH group, the patients had 2 laboratorial serum determinations with a minimum interval period of 6 weeks, both TSH levels above normal upper limit (4.0 μUI/mL), and free thyroxine (FT4) were in the normal range (0.9–1.8 ng/dL). Manifest hypothyroidism (MH) patients had low FT4
Results
Overall, 226 participants were included within the years of 2001 and 2006. Of those participants, 133 patients had SH (6 patients were men), 23 patients had MH (all of them were women), and 70 patients (2 men) had no thyroid dysfunction.
Spontaneous hypothyroidism was the more prevalent etiology of disease in the group, but 9 patients (SH = 8) had history of ablative therapy for Graves disease, and 7 patients had been thyroidectomized for benign nodular disease (SH = 6). The presence of TPO-Ab
Discussion
The findings of the current study suggest that SH might be an intermediate state between EU and MH. It was demonstrated that the lipid profile of SH patients did not differ significantly from EU, except in the subgroups of patients with positive TPO-Ab and TSH greater than 8.0 μUI/mL.
Although not statistically significant, when compared with the EU group, the means of all lipid variables of the study were greater in SH. In addition, the means were lesser than those of MH group, except for
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