Diastolic Heart Failure: Definitions and Terminology
Section snippets
Comparison Between SHF and DHF
Patients with CHF can be divided into 2 broad categories: systolic heart failure (SHF) and DHF. There are significant differences in demographics, prognosis, left ventricular (LV) structure, and function between these 2 groups of patients (Table 1, Table 2).2, 4, 5, 19
Patients with SHF have eccentric remodeling, increased LV diastolic volume, and predominant abnormalities in LV systolic properties including decreased systolic performance, function, and contractility.5, 20, 21 Effective arterial
Acknowledgments
This publication was supported by a grant from the Research Service of the Department of Veterans Affairs (MR Zile) and from the National Heart, Lung, Blood Institute (grant PO1-HL-48788, MR Zile).
References (38)
- et al.
Congestive heart failure in subjects with normal versus reduced left ventricular ejection fraction. Prevalence and mortality in a population-based cohort
J. Am. Coll. Cardiol.
(1999) Heart failure with preserved ejection fraction: Is this diastolic heart failure?
J. Am. Coll. Cardiol.
(2003)- et al.
Changes in notions about heart failure
Lancet
(2001) - et al.
Diastolic heart failure: Neglected or misdiagnosed?
J. Am. Cardiol.
(2002) - et al.
A phase II, double-blind, randomized, placebo-controlled, dose comparative study of the efficacy, tolerability, and safety of MCC-135 in subjects with chronic heart failure, NYHA class II/III (MCC-135-GO1 Study): Rationale and design
J. Card. Fail.
(2004) - et al.
Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: The CHARM-Preserved Trial
Lancet
(2003) - et al.
Ventricular remodeling in heart failure: A credible surrogate endpoint
J. Card. Fail.
(2003) - et al.
Cardiac cycle–dependent changes in aortic area and distensibility are reduced in older patients with isolated diastolic heart failure and correlate with exercise intolerance
J. Am. Coll. Cardiol.
(2001) - et al.
Mortality and readmission of hospitalized patients with congestive heart failure and preserved versus depressed systolic function
Am. J. Cardiol.
(2001) - et al.
Losartan improves exercise tolerance in patients with diastolic dysfunction and a hypertensive response to exercise
J. Am. Coll. Cardiol.
(1999)
Color tissue Doppler–derived long-axis left ventricular function in heart failure with preserved global systolic function
Am. J. Cardiol.
Ventricular remodeling without cellular contractile dysfunction
J. Card. Fail.
New concepts in diastolic dysfunction and diastolic heart failure: Part I. Diagnosis, prognosis, measurements of diastolic function
Circulation
Left ventricular diastolic dysfunction and diastolic heart failure
Annu. Rev. Med.
Burden of systolic and diastolic ventricular dysfunction in the community. Appreciating the scope of the heart failure epidemic
JAMA
How to diagnose diastolic heart failure
Eur. Heart. J.
Defining diastolic heart failure. A call for standardized diagnostic criteria
Circulation
The pathogenesis of acute pulmonary edema associated with hypertension
N. Engl. J. Med.
Heart failure with a normal ejection fraction. Is measurement of diastolic function necessary to make the diagnosis of diastolic heart failure?
Circulation
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