Inhibitory effect on cerebral inflammatory agents that accompany traumatic brain injury in a rat model: A potential neuroprotective mechanism of recombinant human erythropoietin (rhEPO)
Section snippets
Acknowledgments
We thank Dr. Bo Wu and Dr. Geng-bao Feng for their technical assistance.
References (32)
- et al.
Erythropoietin exerts an anti-inflammatory effect on the CNS in a model of experimental autoimmune encephalomyelitis
Brain Res.
(2002) - et al.
NF-κB: 10 years after
Cell
(1996) - et al.
Signalling through the JAK-STAT pathway in the developing brain
Trends Neurosci.
(1999) - et al.
Cortical expression of nuclear factor kappaB after human brain contusion
Brain Res.
(2006) - et al.
Effect of systemic LPS injection on cortical NF-kappaB activity and inflammatory response following traumatic brain injury in rats
Brain Res.
(2004) - et al.
Erythropoietin receptor-mediated inhibition of exocytotic glutamate release confers neuroprotection during chemical ischemia
J. Biol. Chem.
(2001) - et al.
Erythropoietin is neuroprotective in models of HIV sensory neuropathy
Neurosci. Lett.
(2004) - et al.
Mechanism of the cardioprotection of rhEPO pretreatment on suppressing the inflammatory response in ischemia-reperfusion
Life Sci.
(2006) - et al.
Cytokines in inflammatory brain lesions: helpful and harmful
Trends Neurosci.
(1996) - et al.
Recombinant human erythropoietin decreases myeloperoxidase and caspase-3 activity and improves early functional results after spinal cord injury in rats
J. Clin. Neurosci.
(2007)
Antioxidant properties of propofol and erythropoietin after closed head injury in rats
Prog. Neuropsychopharmacol. Biol. Psychiatry
Erythropoietin prevents hypoxia/ischemia-induced DNA fragmentation in an experimental model of perinatal asphyxia
Neurosci. Lett.
Effect of betamethasone on neuropathic pain and cerebral expression of NF-kappaB and cytokines
Neurosci. Lett.
Intranasal recombinant human erythropoietin protects rats against focal cerebral schemia
Neurosci. Lett.
Secondary insults worsen blood brain barrier dysfunction assessed by MRI in cerebral contusion
Acta Neurochir. Suppl.
Erythropoietin crosses the blood–brain barrier to protect against experimental brain injury
Proc. Natl. Acad. Sci. U.S.A.
Cited by (114)
Neuroprotective effect of 25-Methoxyhispidol A against CCl<inf>4</inf>-induced behavioral alterations by targeting VEGF/BDNF and caspase-3 in mice
2020, Life SciencesCitation Excerpt :The productions of pro-inflammatory cytokines in HC and PFC region of mice brain were analyzed by using ELISA kits (eBioscience Inc., USA) [38]. Frozen brain (HC and PFC) samples were homogenized in 1 mmol/l of PMSF, 1 mg/l of pepstatin A, 1 mg/l of aprotinin, and 1 mg/l of leupeptin in PBS solution (pH 7.2) and then centrifuged at 12,000 g for 20 min at 4 °C [39]. The concentration of cytokines in the tissue from all the groups i.e., vehicle control, CCl4, and 25-MHA treated groups were determined according to the manufacturer's protocol.
Inhibition of mammalian target of rapamycin attenuates early brain injury through modulating microglial polarization after experimental subarachnoid hemorrhage in rats
2016, Journal of the Neurological SciencesCitation Excerpt :To ensure reproducibility, all experiments were repeated at least three times. The levels of inflammatory mediators were quantified using specific ELISA kits for rats according to the manufacturers' instructions (TNF-α, IL-1β from BioSource Europe SA, Nivelles, Belgium) and our previous study [23]. Values were expressed as ng/g protein.
Pathological changes in the brain after peripheral burns
2023, Burns and Trauma