Original ArticlePerinatal Asphyxia with Hyperoxemia within the First Hour of Life Is Associated with Moderate to Severe Hypoxic-Ischemic Encephalopathy
Section snippets
Methods
This was a retrospective cohort study conducted at Parkland Memorial Hospital in Dallas, Texas, which has a high-risk perinatal service with ∼15 000 deliveries annually and is a regional level III neonatal intensive care unit (NICU) receiving 1300-1500 admissions each year. This project was approved by the Institutional Review Board of the University of Texas Southwestern Medical Center. Subjects were identified by retrospective review of 2 prospectively collected databases, the Parkland
Results
Of the 60 743 infants born occurring at Parkland Hospital during the study period, 4815 were admitted to the NICU, and 120 met our eligibility criteria for this study (Figure 1). Among the eligible infants, 36 (30%) had hyperoxemia at admission and 84 (70%) did not have hyperoxemia. Maternal perinatal risk factors, including age and rates of preeclampsia, prolonged rupture of membranes, chorioamnionitis, presence of meconium-stained amniotic fluid, abruption, fetal heart rate deceleration, and
Discussion
Here we report an association between hyperoxemia on admission to the NICU within the first hour of life in neonates with perinatal acidemia and the development of moderate to severe HIE in these neonates. In our series, the incidence of HIE was associated with the degree of hyperoxemia on admission. In addition, neonates with moderate-severe HIE demonstrated an association between early hyperoxemia and abnormal brain MRI performed between 5 and 10 days of life.
Our study examined all inborn
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The authors declare no conflicts of interest.