Elsevier

Fertility and Sterility

Volume 96, Issue 4, October 2011, Pages 820-825
Fertility and Sterility

Seminal contribution
The effect of increasing obesity on the response to and outcome of assisted reproductive technology: a national study

Presented at the 66th annual meeting of the American Society for Reproductive Medicine, which was held in Denver, Colorado, on October 23–27, 2010.
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Objective

To evaluate the effect of increasing female obesity on response to and outcome of assisted reproductive technology (ART) treatment.

Design

Historical cohort study.

Setting

Clinic-based data.

Patient(s)

A total of 152,500 ART cycle starts from the Society for Assisted Reproductive Technology Clinical Outcomes Reporting System for 2007–2008, limited to women with documented height and grouped by body mass index (BMI, [weight/height2]).

Intervention(s)

None.

Main Outcome Measure(s)

Cycle cancellation overall, cycle cancellation due to low response, treatment failure (not pregnant vs. pregnant), and pregnancy failure (fetal loss or stillbirth vs. live birth), as adjusted odds ratios and 95% confidence intervals, with cycles among normal-weight women as the reference group.

Result(s)

Cycle cancellation overall and cancellation due to low response using autologous oocytes significantly paralleled increasing BMI. The odds of treatment failure rose significantly with autologous-fresh cycles, from 1.03 for cycles among overweight women (BMI 25.0–29.9) to 1.53 for cycles among women with BMIs ≥50.0 kg/m2. Likewise, the odds of pregnancy failure were most significant with increasing BMI among women with autologous-fresh cycles, increasing from 1.10 for cycles to overweight women to 2.29 for cycles to women with BMI ≥50.0 kg/m2.

Conclusion(s)

These results indicate significantly higher odds of cycle cancellation. In addition, treatment and pregnancy failures with increasing obesity significantly increased starting with overweight women.

Key Words

Obesity
assisted reproductive technology
response to treatment
pregnancy

Cited by (0)

B.L. has nothing to disclose. M.B.B. has nothing to disclose. S.A.M. has nothing to disclose. O.B. has nothing to disclose. R.L. has nothing to disclose. J.E.S. has nothing to disclose.

This study was supported by the Society for Assisted Reproductive Technology.