NotesUse of tigecycline for the treatment of prolonged bacteremia due to a multiresistant VIM-1 and SHV-12 β-lactamase–producing Klebsiella pneumoniae epidemic clone
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Acknowledgments
β-Lactamase identifications and time killing studies were performed through a research grant from Instituto de Salud Carlos III, Ministry of Health (FIS PI060806) and the Microbial Sciences Foundation (Madrid, Spain). M. Tato is a recipient of a contract from the Instituto de Salud Carlos III Spain (CM06/00044). The authors did not receive compensation for either their participation as investigators in this study or for the writing of this article.
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2011, The Lancet Infectious DiseasesCitation Excerpt :In the Greek case series152 including 14 cases of bacteraemia and three cases of ventilator-associated pneumonia, which were caused by blaVIM-1-producing enterobacteria,152 tigecycline was active against all isolates. Tigecycline was also successfully used to treat a patient with prolonged bacteraemia that was caused by VIM-1-producing and SHV-12-producing K pneumonia.156 However, the low serum concentrations of tigecycline suggest the need for caution and careful assessment of the MIC values before using this drug for bloodstream infections.157