Decreasing incidence of type 2 diabetes mellitus in the United States, 2007–2012: Epidemiologic findings from a large US claims database
Introduction
Diabetes continues to pose a substantial global healthcare challenge with marked medical and socioeconomic ramifications. Recent estimates from the International Diabetes Federation suggest that 415 million adults worldwide were living with diabetes in 2015 (1 in 11 adults), and that as many as 642 million people (1 in 10 adults) may be affected by the year 2040 [1]. In the US alone, 29.3 million adults had a diagnosis of diabetes in 2015 [1]. Worldwide, most countries spend between 5% and 20% of all healthcare dollars on diabetes [1]. In the US, the estimated national cost of diabetes in 2015 was $320 billion [1]. Data from 2012 indicated that costs associated with diabetes accrue from a combination of direct health expenditures (72%) and indirect costs from productivity losses, job absenteeism, unemployment, and premature mortality (28%) [2].
Given the large number of people affected by diabetes, the majority of whom have type 2 diabetes mellitus (T2D), trends in prevalence and incidence are of interest for gauging the impact of disease prevention efforts and forecasting future healthcare resource needs. The purpose of this study was to explore epidemiological trends in T2D in the US between 2007 and 2012. This was accomplished using a large US claims database from which objective data pertaining to demographics, medical services for T2D (according to ICD-9 codes), and prescriptions for T2D drugs were analyzed for 1.2 million and 2.0 million T2D patients in 2007 and 2012, respectively. The objectives of the study were to ascertain changes between the two study years in T2D incidence and prevalence, demographic characteristics of T2D patients, and patterns of comorbidities related to T2D. Trends derived from the analyses of these real-world data could be useful for allocating healthcare resources.
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Subjects
The Truven Health MarketScan® Databases were used for cross-sectional analyses. These databases include claims from persons residing in all states of the US, include only de-identified data, and are fully compliant with the Health Insurance Portability and Accountability Act of 1996. The Commercial Claims and Encounters (CCAE) database is a collection of inpatient, outpatient, and pharmaceutical claims from over 200 US insurance carriers and large, self-insuring companies. The Medicare
Variables
The variables examined included age, sex, and geographical location, as well as type of insurance (commercial vs Medicare). Geographic regions of the US were defined as Central, Northeast, South, and West. Comorbidities were identified using ICD-9 codes in claims during the analysis years (2007 and 2012). The comorbidities examined included those known to be commonly associated with diabetes and included hypertension, hyperlipidemia, cardiovascular diseases, cerebrovascular diseases, peripheral
Prevalence population
The total numbers of enrolled persons in the databases were 15.07 million in 2007 and 24.52 million in 2012 (Table 1). Of these, 1.2 million were diagnosed with T2D in 2007, and 2.04 million were diagnosed in 2012, for a T2D prevalence of 8.2% in 2007 and 8.3% in 2012. Slightly more men than women had T2D, with men accounting for 52.5% of the diabetes population in 2007 and 52.1% in 2012.
In both years, T2D prevalence was markedly greatest among patients 60 years and over compared with younger
Discussion
This analysis of a very large claims database analysis, including more than 15 million patients in 2007 and more than 24 million patients in 2012, highlights a number of important results and trends in the epidemiology of T2D and its associated comorbidities in the US.
The mean age of patients with prevalent T2D was similar in 2007 and 2012. However, the mean age of newly-diagnosed T2D patients decreased by 3 years from 2007 to 2012, while the mean ages for the overall database populations in the
Conflicts of interest
WW, EK, TH, SK, BS and JB are employees of, and stock/shareholders in, Novo Nordisk Inc. YL was a contract employee of Novo Nordisk, Inc. at the time the study was performed (currently employed at Truven Health Analytics, Cambridge, MA, USA).
Acknowledgements
This study was funded by Novo Nordisk Inc. (Plainsboro, NJ); editorial assistance for this paper was provided by Churchill Communications (Maplewood, NJ) with funding from Novo Nordisk Inc.
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