Neurology/original researchA Multicenter Evaluation of the ABCD2 Score's Accuracy for Predicting Early Ischemic Stroke in Admitted Patients With Transient Ischemic Attack
Introduction
A systematic review of 18 independent patient cohort studies concluded that the 7-day risk of a completed ischemic stroke among patients receiving a diagnosis of a transient ischemic attack is 5%.1 Because most patients receiving a diagnosis of transient ischemic attack are not at high short-term risk of a completed stroke after their initial event, stroke prediction tools could be valuable in guiding emergency medicine practice and the urgency of transient ischemic attack evaluation. Among transient ischemic attack clinical risk stratification scores, the ABCD2 score has emerged as the most refined tool, consisting of a simple 7-point risk score derived from age (A), blood pressure (B), clinical features (weakness/speech disturbance) (C), transient ischemic attack duration (D), and diabetes history (D).2 However, it lacks independent, prospective validation in an adequately powered, broad patient population.2, 3, 4
Our study evaluates the accuracy of the ABCD2 score for predicting risk of ischemic stroke within 7 days in a large, multicenter population of patients admitted to the hospital with transient ischemic attack. Because no criterion standard exists that distinguishes minor stroke from transient ischemic attack, we included disabling stroke as an important patient-oriented outcome because it is uncontroversially distinguished from transient ischemic attack. Additionally, because a proposed application of the ABCD2 score among emergency medicine practitioners is to identify patients at low risk for early stroke,5 we analyzed the sensitivity of a low-risk ABCD2 score to identify patients with transient ischemic attack and low risk for early stroke.
Section snippets
Study Design
Our study used prospective, nonconsecutive, sample cohort enrollment and data collection, with medical record review at 90 days to determine outcome.
Setting
The North Carolina Collaborative Stroke Registry is one of 4 state registries funded by the Centers for Disease Control and Prevention in the Paul Coverdell National Acute Stroke Registry program. We invited all 25 North Carolina Collaborative Stroke Registry hospitals in 2005 to participate in our ancillary, separately funded project. Sixteen of
Results
During a 35-month period, we enrolled 1,667 patients presenting within 24 hours of symptom onset with a presumptive diagnosis of transient ischemic attack and no history of stroke (Table 1). A total of 373 patients (23%) received a diagnosis of an ischemic stroke within 7 days, of which 353 occurred within 2 days (91%). Eighteen percent (69/373) of all strokes occurring within 7 days were disabling. The majority of all strokes met the outcome classification of an imaging-positive stroke (97%,
Limitations
Despite the strength of our prospective enrollment and the large number of patients included from a variety of hospital settings, our study has several limitations. We limited our analysis to admitted patients with transient ischemic attack, who were urgently evaluated and treated. The number of patients with transient ischemic attack discharged home from the emergency department (ED) at each site and not enrolled is unknown. In an effort to determine the effect of this limitation, the study
Discussion
Several investigators have reported their experience with the ABCD2 score's predecessor rule (the ABCD score), with disparate results,15, 16, 20, 23, 29 which reinforces the need for prospective validation of the refined ABCD2 rule before widespread adoption by emergency physicians. Previous attempts to independently validate the ABCD2 score have been underpowered to reach conclusive results or have considered enrollment or follow-up periods beyond periods pertinent to ED decisionmaking.30, 31,
Appendix
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2013, Annals of Emergency Medicine
Please see page 202 for the Editor's Capsule Summary of this article.
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Supervising editor: Robert Silbergleit, MD
Author contributions: AWA conceived the study, obtained research funding, and recruited participating centers. AWA, AMJ, WDR, CHT, and AF designed the trial. AWA, WDR, MFP, and CVM supervised the conduct of the trial and data collection. AWA, MFP, SS, CHT, and AF performed some data collection. MFP and CVM managed the data, including quality control. AMJ, WDR, KMR, and DC provided statistical advice on study design and supervised data analysis. AMJ performed all data analyses. AWA drafted the article, and AMJ, WDR, and KMR contributed substantially to its revision. AWA takes responsibility for the paper as a whole.
Funding and support: By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article that might create any potential conflict of interest. See the Manuscript Submission Agreement in this issue for examples of specific conflicts covered by this statement. This work was supported by the Emergency Medicine Foundation and the Foundation for Education and Research in Neurological Emergencies, along with a grant from Boehringer Ingelheim Pharmaceuticals, Inc.
Publication date: Available online June 24, 2009.
Reprints not available from the authors.