EPIDEMIOLOGY OF LATE DIABETIC COMPLICATIONS: A Basis for the Development and Evaluation of Preventive Programs

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Cumulative Incidence of Retinopathy According to Diabetes Duration

The most frequent late complication of IDDM is retinopathy. Following the onset of IDDM, there is a lag period of about 3 to 4 years before the first cases of nonproliferative retinopathy are seen.19, 53, 105 The risk then increases exponentially. During the fifth year of IDDM, nonproliferative retinopathy develops in 1 of 100 patients, whereas in the fourteenth year, it develops in 11 of 100 patients who have escaped it up to that time.3 By the fifteenth year of IDDM, the cumulative incidence

Cumulative Incidence of Diabetic Kidney Disease According to Diabetes Duration

The natural history of diabetic kidney disease has generally been viewed as a descending path from normoalbuminuria to end-stage renal disease through intermediate stages marked by microalbuminuria and then overt proteinuria.91The prevalence of these stages of diabetic kidney disease in IDDM is summarized according to the duration of diabetes in Figure 3Because several studies have demonstrated that the duration of diabetes before puberty does not contribute to the risk of diabetic kidney

DIABETES AND CORONARY ARTERY DISEASE

In contrast to ocular and renal complications, which occur in patients with diabetes in all populations, coronary artery disease is a frequent complication in diabetic patients mainly in populations in which there is a high risk of coronary artery disease in individuals without diabetes. The excess coronary artery disease in patients with diabetes in these populations is independent of the frequency and level of conventional risk factors for coronary artery disease.51, 123The following review

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References (145)

  • B.C. Martin et al.

    Role of glucose and insulin resistance in development of type 2 diabetes mellitus: Results of 25-year follow-up study

    Lancet

    (1992)
  • S.E. Moss et al.

    Ocular factors in the incidence and progression of diabetic retinopathy

    Ophthalmology

    (1994)
  • J. Allawi et al.

    Microalbuminuria in non-insulin-dependent diabetes: Its prevalence in Indian compared with Europid patients

    BMJ

    (1988)
  • T. Almdal et al.

    The predictive value of microalbuminuria in IDDM

    Diabetes Care

    (1994)
  • A.R. Andersen et al.

    Diabetic nephropathy in type I (insulin-dependent) diabetes: An epidemiological study

    Diabetologia

    (1983)
  • D.J. Ballard et al.

    Epidemiology of persistent proteinuria in type II diabetes mellitus: Population-based study in Rochester, Minnesota

    Diabetes

    (1988)
  • Bennett PH, Lee ET, Lu M, and WHO MSVDD: Prevalence of abnormal albumin excretion and its association with vascular...
  • M. Bojestig et al.

    Unchanged incidence of laser-treatment retinopathy during the last 20 years in patients with IDDM [abstract]

    Acta Endocrinol

    (1993)
  • M. Bojestig et al.

    Declining incidence of nephropathy in insulin-dependent diabetes mellitus

    N Engl J Med

    (1993)
  • K. Borch-Johnsen et al.

    Proteinuria: Value as predictor of cardiovascular mortality in insulin dependent diabetes mellitus

    BMJ

    (1987)
  • K. Borch-Johnson et al.

    Is diabetic nephropathy an inherited complication?

    Kidney Int

    (1992)
  • M. Brownlee et al.

    Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications

    N Engl J Med

    (1988)
  • P.H. Chase et al.

    Glucose control and the renal and retinal complications of insulin-dependent diabetes

    JAMA

    (1989)
  • B.M. Chavers et al.

    Relationship between retinal and glomerular lesions in IDDM patients

    Diabetes

    (1994)
  • Cohen R, Manson J, Krolewski A, et al and the Sorbinil Retinopathy Trial (SRT) Research Group: Determinants of...
  • B.A. Coonrod et al.

    Predictors of microalbuminuria in individuals with IDDM

    Diabetes Care

    (1993)
  • C.C. Cowie et al.

    Disparities in the incidence of diabetic end-stage renal disease according to race and type of diabetes

    N Engl J Med

    (1989)
  • T. Danne et al.

    Long-term glycemic control as a nonlinear association to the frequency of background retinopathy in adolescents with diabetes

    Diabetes Care

    (1994)
  • DCCT Research Group

    The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus

    N Engl J Med

    (1993)
  • The Diabetes Control and Complications Trial (DCCT) Research Group

    Effect of intensive diabetes management on macrovascular events and risk factors in the diabetes control and complications trial

    Am J Cardiol

    (1995)
  • Diabetes Control and Complication Trial Research Group

    Progression of retinopathy with intensive versus conventional treatment in the diabetes and complications trial

    Ophthalmology

    (1995)
  • Diabetes Drafting Group

    Prevalence of small vessel and large vessel disease in diabetic patients from 14 centers: The WHO Multinational Study of Vascular Disease in Diabetics

    Diabetologia

    (1985)
  • K. Earle et al.

    Familial clustering of cardiovascular disease in patients with insulin-dependent diabetes and nephropathy

    N Engl J Med

    (1992)
  • E. Eschwege et al.

    Coronary heart disease mortality in relation with diabetes, blood glucose and plasma insulin levels: The Paris prospective study, ten years later

    Horm Metab Res

    (1985)
  • ETDRS Investigators: Aspirin effect on mortality and morbidity in patients with diabetes mellitus: Early Treatment Diabetic Retinopathy Study Report 14

    JAMA

    (1992)
  • S.E. Fagerberg

    Diabetic neuropathy: A clinical and histological study of the significance of vascular affections

    Acta Med Scand

    (1959)
  • A. Fontbonne

    Why can high insulin levels indicate a risk for coronary heart disease?

    Diabetologia

    (1994)
  • A. Fontbonne et al.

    Body fat distribution and coronary heart disease mortality in subjects with impaired glucose tolerance or diabetes mellitus: The Paris Prospective Study, 15-year follow-up

    Diabetologia

    (1992)
  • C.M. Forsblom et al.

    Predictive value of microalbuminuria in patients with insulin-dependent diabetes of long duration

    BMJ

    (1992)
  • J. Fujita et al.

    Erythrocyte sodium-lithium countertransport activity as a marker of predisposition to hypertension and diabetic nephropathy in NIDDM

    Diabetes Care

    (1994)
  • M.A. Gall et al.

    Albuminuria and poor glycemic control predict mortality in NIDDM

    Diabetes

    (1995)
  • A.J. Gay et al.

    Retinal artery pressure in asymmetric diabetic retinopathy

    Arch Ophthalmol

    (1966)
  • C.B. Grange et al.

    Outcome of patients with diabetes mellitus and acute myocardial infarction treated with thrombolytic agents: The thrombolysis and angioplasty in myocardial infarction (TAMI) study group

    J Am Coll Cardiol

    (1993)
  • S.M. Haffner et al.

    Cardiovascular risk factors in confirmed prediabetic individuals: Does the clock for coronary heart disease start ticking before the onset of clinical diabetes?

    JAMA

    (1990)
  • J. Head et al.

    International variation in mortality among diabetic patients: The WHO multinational study of vascular disease in diabetics

    Diabetologia

    (1990)
  • P.R. Hebert et al.

    Pharmacologic therapy of mild to moderate hypertension: Possible generalizability to diabetics

    J Am Soc Nephrol

    (1992)
  • R.M. Hillson et al.

    Hyperinsulinemia is associated with development of electrocardiographic abnormalities in diabetics

    Diabetes Res

    (1984)
  • G. Howard et al.

    Lower insulin sensitivity is related to atherosclerosis in non-diabetics: The Insulin Resistance Atherosclerosis Study (IRAS)

    Diabetes

    (1994)
  • L.L. Humphrey et al.

    Chronic renal failure in non-insulin-dependent diabetes mellitus

    Ann Intern Med

    (1989)
  • H.U. Janka et al.

    Risk factors for progression of background retinopathy in long-standing IDDM

    Diabetes

    (1989)
  • Cited by (0)

    Address reprint requests to Andrzej S. Krolewski, MD, PhD, Section of Epidemiology and Genetics, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215

    Supported by National Institutes of Health grant RO1 41526

    *

    From the Section of Epidemiology and Genetics, Research Division, Joslin Diabetes Center (all authors); the Department of Medicine, Harvard Medical School (ASK, MBSF); and the Department of Epidemiology, Harvard School of Public Health (ASK, JHW), Boston, Massachusetts

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