Sex-related differences in response of plasma lipids to simvastatin: The Saitama Postmenopausal Lipid Intervention study
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Cited by (14)
Gender-related lipid and/or lipoprotein responses to statins in subjects in primary and secondary prevention
2015, Journal of Clinical LipidologyCitation Excerpt :A more detailed analysis of the 2 studies shows that S-POLIS included a total of only 177 patients (122 women and 55 men) treated only with simvastatin at different daily doses, compared with the 337 patients (171 men and 166 women) in our study, treated with all major statins. Furthermore, a statistically significant difference in TC and LDL-C between the 2 genders was present at baseline in S-POLIS21 vs no differences in the present report (Table 1). Two studies in Chinese populations reported instead a lesser cholesterol reduction in statin-treated women, after adjustment for a number of covariates22 and a reduced number of coronary heart disease in women vs men achieving the LDL-C target, despite a large prescription of statin therapy.23
Statins Personalized
2012, Medical Clinics of North AmericaCitation Excerpt :Low alcohol consumption was associated with greater LDL-C reduction from pravastatin therapy.40 Postmenopausal women treated with simvastatin achieved significantly greater LDL-C reduction compared with men (-28% vs -20%, respectively) when the dose effect was calibrated by body weight.41 However, further studies in these areas are needed because these effects were not consistent across a limited number of studies.33,37,42
A gene score of nine LDL and HDL regulating genes is associated with fl uvastatin-induced cholesterol changes in women
2010, Journal of Lipid ResearchCitation Excerpt :Sakabe et al. (43) found that 3 months atorvastatin treatment lowered small dense LDL more in women than in men. Nakajima (44) noted a greater LDL reduction in women than in men with hypercholesterolemia after 12 months of simvastatin treatment. Fluvastatin pharmacokinetics has not been shown to be different among sexes (45).
Are There Sex-Specific Differences in Response to Adjunctive Host-Directed Therapies for Tuberculosis?
2020, Frontiers in Immunology
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Members of the S-POLIS Group are listed in the Acknowledgments.