ViewpointInfection, inflammation, and infarction: does acute endothelial dysfunction provide a link?
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2018, Environment InternationalCitation Excerpt :Plausible mechanisms for this include a number of pro-inflammatory, pro-coagulant and haemodynamic effects induced by infections, which may lead to cardiac complications. For example, increased concentrations of C reactive protein (CRP) are associated with increased risk of AMI (Kuller et al., 1996; Ridker et al., 2000)) and the systemic inflammation associated with an acute respiratory tract infection (or directly as a result of cold exposure) can result in altered endothelial function or be associated with plaque rupture (Vallance et al., 1997). Cardiovascular events may also be triggered by indirect behavioural mechanisms, such as reduced mobility (e.g. brought about by people being less mobile in the cold, or being unwilling to move outside heated areas of homes) which can lead to deep vein thrombosis and pulmonary embolisms.