Elsevier

The Lancet

Volume 294, Issue 7635, 27 December 1969, Pages 1380-1382
The Lancet

ORIGINAL ARTICLES
RISKS OF ISCHÆMIC HEART-DISEASE IN FAMILIAL HYPERLIPOPROTEINÆMIC STATES

https://doi.org/10.1016/S0140-6736(69)90930-1Get rights and content

Abstract

The life experience of 104 patients with Summary Fredrickson's type-II hyperbetalipo-proteinæmia has been compared with 41 patients with hyperlipoproteinæmia associated with hypertriglyceridæmia (Fredrickson's types III, IV, and v hyperlipoproteinsemia). Of 21 male index patients with type-II hyperbetalipoproteinæmia 15 developed ischæmic heart-disease (I.H.D.) at mean age 42.7 years, and 2 have died. 20 out of 30 biochemically affected male relatives developed I.H.D. at mean age 43.8 years with 12 deaths. Of 23 female index patients 20 developed I.H.D. at mean age 48.4 years with 4 deaths. 9 out of 30 affected female relatives developed I.H.D. at mean age 57.1 years with 2 deaths. Of the group of 29 male index patients and 5 affected male relatives with types III, IV, and v hyperlipoproteinæmia, 12 developed at mean age 48.7 years, 10 having intermittent claudication and none have died. The 7 female patients are all alive, 5 developed I.H.D. at mean age sixty-five. For men with type-II hyperbetalipoproteinæmia the chance of a first attack of I.H.D. was 5.4% by age thirty, 51.4% by age fifty, and 85.4% by age sixty. For women the risks were 0, 12.2%, and 57.5% respectively. For men with types III, IV, and v hyperlipoproteinæmia the risks were lower (0, 30, and 53.3%) but the risk of peripheral vascular disease was increased.

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