Research LettersAminopeptidase P in individuals with a history of angio-oedema on ACE inhibitors
References (5)
- et al.
Plasma bradykinin in angio-oedema
Lancet
(1998) - et al.
Drug-induced angioedema without urticaria
Drug Saf
(2001)
Cited by (166)
The Importance of Complement Testing in Acquired Angioedema Related to Angiotensin-Converting Enzyme Inhibitors
2021, Journal of Allergy and Clinical Immunology: In PracticeCitation Excerpt :ACEI-AAE belongs to the group of bradykinin-mediated acquired angioedemas (Figure 1).14-18 In human plasma, several enzymes are involved in the breakdown of bradykinin but the ACE is the most important.19-22 The inhibition of ACE with ACEIs results in an elevated plasma bradykinin level.
ACE inhibitor-mediated angioedema
2020, International ImmunopharmacologyCitation Excerpt :Further catabolism of bradykinin is operated sequentially by DPPIV. Plasma activity of APP or DPPIV are reduced in patients experiencing ACEi-AE, compared to controls [20,53]. Genetic analysis of the XPNPEP2 gene, a X-linked gene that codifies for membrane-bound APP, led to the identification of a single nucleotide polymorphism (SNP) in the enhancer region C-2399A (rs3788853) that segregated in 7 families that included cases of ACEi-AE or anaphylactoid reaction during hemodialysis [54].
Biological diagnosis of bradykinin mediated angioedema: CREAK recommendations
2019, Presse MedicaleCardiovascular and Diabetic Medications That Cause Bradykinin-Mediated Angioedema
2017, Journal of Allergy and Clinical Immunology: In PracticeThe Angiotensin-Converting-Enzyme-Induced Angioedema
2017, Immunology and Allergy Clinics of North AmericaCitation Excerpt :Other proteases besides ACE (aminopeptidase P, dipeptidylpeptidase IV, carboxpeptidase N) also partake in bradykinin degradation. If they are inhibited in addition to ACE, then one may see an extra increase in plasma and tissue bradykinin concentrations.9–11 Bradykinin receptors are G-protein–coupled receptors that are present ubiquitously on cell membranes.
PGX: Pharmacogenomics During Generation X
2016, Advances in Chronic Kidney Disease