Original articlePsychological effects of continuation versus discontinuation of hormone replacement therapy by estrogen implants: A placebo-controlled study
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Sex differences in the blood–brain barrier: Implications for mental health
2022, Frontiers in NeuroendocrinologyCitation Excerpt :In vitro studies and surgical approaches such as OVX have yielded important discoveries that helped to better understand estrogen-mediated modulation of BBB integrity; however, they fail to replicate the natural cycling levels of gonadal hormones. Thus, these findings may not translate readily to mental health research in humans, which is probably why estrogen replacement therapy has shown mixed results in human cohorts (Pearce et al., 1997; Weiser et al., 2019). Another major limitation of these studies in the context of mental disorder research is the lack of investigation for behavioral endpoints.
Urinary phytoestrogens and depression in perimenopausal US women: NHANES 2005-2008
2014, Journal of Affective DisordersCitation Excerpt :There is some evidence that hormone therapy (HT) improves psychological well-being of menopausal women (Haines et al., 2003). Soares et al. found that the transdermal oestradiol therapy had a significant antidepressant effect in perimenopausal women, whereas Pearce et al. observed that HT did not affect depression or anxiety (Pearce et al., 1997; Soares et al., 2001). To prevent potential medical risks associated with the use of HT, it may be of interest to evaluate the effect of natural estrogens such as phytoestrogens on the risk of depression in perimenopausal women.
The menopause: A signal for the future
2007, MenopauseThe Menopause: A Signal for the Future
2007, Treatment of the Postmenopausal Woman: Basic and Clinical Aspects, Third Edition