Group B streptococcal carriage and disease: A 6-year prospective study

doi:10.1016/S0022-3476(87)80283-4

The Journal of Pediatrics

Volume 110, Issue 1, January 1987, Pages 31-36

https://doi.org/10.1016/S0022-3476(87)80283-4 Get rights and content

A prospective study of group B streptococcal (GBS) carriage and disease was conducted over 6 years. Carriage rates at delivery for mothers and infants were 20% and 12%, respectively. Forty-five cases of GBS disease occurred in infants, 24 “early-onset” disease and 21 “late-onset” disease. The combined attack rate for early and late disease was 3.3 per 1000 live births over the 6 years. The rate of early-onset disease was highest in infants found to be heavily colonized at birth: 50 per 1000 live births. Twenty-three of 24 had evidence of intrauterine-acquired infection. All GBS serotypes were represented. Preterm delivery, prolonged labor, premature rupture of membranes, and maternal infection enhanced the risk of early disease. Septicemia was the predominant form of late-onset disease (15 of 21 cases); GBS type III accounted for 19 of 21 cases. Ten of 21 infants with late infections were colonized at birth with the GBS type that subsequently caused disease. Thus a maternal source of infection was identified in 34 of the 45 infants. These data reveal consistent year-to-year carriage and disease rates in the study population.

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^*: Supported by Grants 1-P01-HD-10699 (Project 10) and Program Project 5-P01-HD-17812 from the National Institute for Child Health and Human Development.

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Original articleGroup B streptococcal carriage and disease: A 6-year prospective study*

J Pediatr

J Pediatr

Am J Obstet Gynecol

Am J Obstet Gynecol

Am J Obstet Gynecol

Group B β-hemolytic streptococcal infections in the newborn

Am J Dis Child

Laboratory and field evaluation of selective media for isolation of group B streptococcus

J Clin Microbiol

Modified method for the serological identification of group B streptococci

J Clin Microbiol

Anorectal and vaginal carriage of group B streptococci in pregnant women

J Infect Dis

Selective intrapartum chemoprophylaxis of neonatal group B streptococcal early-onset disease. I. Epidemiologic rationale

J Infect Dis

Selective intrapartum chemoprophylaxis of neonatal group B streptococcal early-onset disease. II. Predictive value of prenatal cultures

J Infect Dis

Selective intrapartum chemoprophylaxis of neontal group B streptococcal early-onset disease. III. Interruption of mother-to-infant transmission

J Infect Dis

Original article
Group B streptococcal carriage and disease: A 6-year prospective study*