Original article
Formaldehyde asthma—Rare or overlooked?

https://doi.org/10.1016/0091-6749(85)90018-1Get rights and content

Abstract

A total of 230 persons who had been exposed to formaldehyde and suffered from asthma-like respiratory symptoms were examined between January 1, 1977, and May 31, 1983. All the subjects had a bronchial provocation test with formaldehyde. On the basis of the medical and occupational history of the patients, the specific bronchial provocation test, and other test results, 12 cases were considered to be caused by specific sensitization to formaldehyde. All subjects had been exposed occupationally. An exposure period of between 1 mo and 19 yr preceded the onset of symptoms. Three persons displayed no bronchial hyperreactivity as assessed with a histamine or metacholine provocation test. Eleven of the 12 reactions were triggered by about 2.5 mg/m3 and one reaction by about 1.2 mg/m3 of formaldehyde. The late reaction in 1 patient was completely blocked by the inhalation of 100 μg of beclomethasone di-isoproprionate before the challenge with formaldehyde. Seventy-one of the 218 subjects who did not react when they were challenged with formaldehyde demonstrated bronchial hyperreactivity. We conclude that formaldehyde asthma, although apparently a rare disease, is under reported. Removal from exposure has a favorable effect on the symptoms. Low domestic exposures, however, may maintain the symptoms in individuals already sensitized.

References (50)

  • W.G. Roths

    Palmar and plantar eczema caused by steam ironing clothes containing formaldehyde

    Berufs-Dermatosen

    (1969)
  • E.J. Kerfoot et al.

    Formaldehyde and paraformaldehyde study in funeral homes

    Am Ind Hyg Assoc J

    (1975)
  • H.P. Blejer et al.

    Occupational health report of formaldehyde concentrations and effects on workers at the Bayly Manufacturing Company, Visalia, Calif

  • J. Radar

    Reizwirkungen von Formaldehyde in Präpariersalen: analytische and experimentelle Untersuchungen

  • I. Andersen et al.

    Controlled human studies with formaldehyde

  • I. Andersen

    Formaldehyde in the indoor environment-health implications and the setting of standards

  • F.N. Marzulli et al.

    Contact allergy: predictive testing in humans

  • B. Magnusson et al.

    Allergic contact dermatitis in the guinea pig

    (1970)
  • E. Cronin

    Formaldehyde

  • W.R. Parkes

    Occupational lung disorders

  • J. Pepys

    Occupational asthma: an overview

    J Occup Med

    (1982)
  • S.M. Brooks

    Bronchial asthma of occupational origin. A review

    Scand J Work Environ Health

    (1977)
  • B. Gandevia

    Occupational asthma

    Med J Aust

    (1970)
  • D.K. Harris

    Health problems in the manufacture and use of plastics

    Br J Ind Med

    (1953)
  • J.B. Schoenberg et al.

    Airway disease caused by phenolic (phenol-formaldehyde) resin exposure

    Arch Environ Health

    (1975)
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