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Herbs as old potential treatments for lymphedema management: A systematic review
2020, Complementary Therapies in MedicineCitation Excerpt :Coumarin alone 27 or combined with troxerutin 30 or diosmin and arbutin 40 was reported to significantly decrease edema volume and improve symptoms. Oxerutin in two RCTs was investigated; in one RCT with 6 months follow-up despite edema reduction, symptoms did not improve significantly 33 however both edema volume and symptoms in the other RCT with one-year follow-up had significant improvement.32 In addition to successful changes in edema volume and related symptoms, treatment with CYCLO 3 FORT 34 and Daflon 35 in two separate RCTs, quality of life and lymphatic circulation improved too respectively.
Furanocoumarins: Biomolecules of therapeutic interest
2014, Studies in Natural Products ChemistryCitation Excerpt :Another trial carried out using coumarin demonstrated that in lymphoedema of the arms and legs, this compound reduced the swelling in the absence of side effects [262]. In addition, the combination treatment of coumarin and the flavonoid troxerutin (Venalot®) has been effective for the treatment of several inflammatory and edematous states and to strengthen the microvasculature [263]. The compound 6,7-dimethoxycoumarin or scoparone isolated from the herb Artemisia scoparia possesses vasodilator and hypolipidemic effects and has been tested in rabbits with hyperlipidemia and diabetogenic condition.
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