Elsevier

Biological Psychiatry

Volume 35, Issue 5, 1 March 1994, Pages 335-344
Biological Psychiatry

Serum antibody for somatostatin-14 and prodynorphin 209–240 in patients with obsessive-compulsive disorder, schizophrenia, Alzheimer's disease, multiple sclerosis, and advanced HIV infection

https://doi.org/10.1016/0006-3223(94)90037-XGet rights and content

Abstract

Patients with obsessive-compulsive disorder (OCD) demonstrated significant levels of antibody for somatostatin-28, its C-terminal fragment somatostatin-14, and prodynorphin. In contrast there were lower levels of reactivity for somatostatin-281–14 (the N-terminal fragment of somatostatin-28) and negligible reactivity for several other peptides including β-endorphin and corticotropin. Healthy volunteers and disease controls [schizophrenia, Alzheimer's disease, multiple sclerosis, and subjects with advanced human immunodeficiency virus (HIV) infection] exhibited negligible reactivity. These data raise the consideration of an autoimmune mechanism for some OCD.

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    This work was supported by a Veterans Affairs Merit Review award and NIMH grant MH43781-02.

    ∗∗

    The authors thank Craig A. Myatt, M.S. for technical advice, Dr. Andrew Goodman for multiple sclerosis sera, and Drs. Anita Feenstra and Darrell Kirch for schizophrenic serum samples.

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