Serum antibody for somatostatin-14 and prodynorphin 209–240 in patients with obsessive-compulsive disorder, schizophrenia, Alzheimer's disease, multiple sclerosis, and advanced HIV infection☆
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Cited by (39)
Obsessive–compulsive disorder
2022, Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders, Second EditionObsessive-compulsive disorder
2012, Handbook of Clinical NeurologyCitation Excerpt :The PANDAS hypothesis was given some support by the observation that the B-lymphocyte antigen D8/17, which is a vulnerability marker for rheumatic fever, was more common in patients with childhood OCD than in controls, although negative results have been reported as well (Murphy et al., 1997; Hoekstra et al., 2004). Serum levels of antibodies for somatostatin-14 and 28, and prodynorphin, which modulate the basal ganglia, have been found to be elevated in OCD by Roy et al. (1994), and Khanna et al. (1997) reported elevated herpes simplex viral antibodies in the cerebrospinal fluid of OCD patients. Despite the possibility of an immediate link between an immune response and the pathophysiology of OCD, the systematic investigation of immune parameters in adult OCD is limited to date.
Prevention and diminished expression of experimental autoimmune encephalomyelitis by low dose naltrexone (LDN) or opioid growth factor (OGF) for an extended period: Therapeutic implications for multiple sclerosis
2011, Brain ResearchCitation Excerpt :Gironi et al. (2000) have reported a reduction in β-endorphin levels in peripheral blood mononuclear cells (PBMCs) from patients with clinically inactive MS, but demonstrated an increase in PBMCs from patients with clinical relapse. No change in another opioid peptide, prodynorphin, has been detected in the blood of patients with MS (Roy et al., 1994). Jankovic (1991) has reported that treatment with [Met5]-enkephalin had a beneficial effect on 13 patients with chronic severe progressive MS. MS patients usually go into remission during pregnancy, and fewer relapses are observed during this period (Csontos et al., 1979).
Naltrexone augmentation in OCD: A double-blind placebo-controlled cross-over study
2008, European NeuropsychopharmacologyInvolvement of Neuropeptide Systems in Schizophrenia: Human Studies
2007, International Review of NeurobiologyCitation Excerpt :Low concentrations of CSF somatostatin were reported in schizophrenic, as well as in other psychiatric patients who were dexamethasone nonsuppressors, suggesting a functional relationship between HPA axis hyperactivity and reduced CSF somatostatin concentrations (Doran et al., 1986; Rubinow, 1986). Both plasma somatostatin concentrations (Saiz‐Ruiz et al., 1992) and serum somatostatin autoantibodies (Rogaeva et al., 1990; Roy et al., 1994) are repeatedly found to be increased in schizophrenic patients. Postmortem studies of somatostatin in schizophrenia consistently demonstrate decreased somatostatin concentrations in the hippocampus of patients with predominant negative symptoms (Ferrier et al., 1983; Roberts et al., 1983).
Review of immunological and immunopathological findings in schizophrenia
2001, Brain, Behavior, and Immunity
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This work was supported by a Veterans Affairs Merit Review award and NIMH grant MH43781-02.
- ∗∗
The authors thank Craig A. Myatt, M.S. for technical advice, Dr. Andrew Goodman for multiple sclerosis sera, and Drs. Anita Feenstra and Darrell Kirch for schizophrenic serum samples.