Brief reportA double blind, placebo-controlled trial of demeclocycline treatment of polydipsia-hyponatremia in chronically psychotic patients
References (14)
- et al.
Demeclocycline improves hyponatremia in chronic schizophrenics
Biol Psychiatry
(1985) Psychosis, inappropriate antidiuretic hormone secretion and water intoxication (letter)
Lancet
(1984)- et al.
Abnormal diurnal weight gain among patients with schizophrenic disorders
Schizophr Res
(1988) - et al.
Treatment of psychosis, intermittent hyponatremia, and polydipsia (PIP syndrome) using lithium and phenytoin
Biol Psychiatry
(1988) - et al.
Comparative effects of tetracyclines on water flow across toad urinary bladders
J Pharmacol Exp Ther
(1974) The design and analysis of clinical experiments
(1986)- et al.
Superiority of demeclocycline over lithium in the treatment of chronic syndrome of inappropriate secretion of antidiuretic hormone
N Engl J Med
(1978)
Cited by (33)
Non-antipsychotic pharmacotherapy of psychogenic polydipsia: A systematic review
2022, Journal of Psychosomatic ResearchCitation Excerpt :There was a decrease in normalized diurnal weight gain in weeks 5–6 only (p ≤ 0.05, Baseline: 5.2 +/− 4.5 lbs., Week 5–6: 2.5 +/− 4.0 lbs.) [26]. Demeclocycline, a semisynthetic tetracycline, was assessed in two studies [25,40]. In a double-blind placebo-controlled case report of one patient, Nixon et al. [43] reported significant reduction in episodes of serum sodium below 135 mEq/L compared to placebo at dosages of 1200 mg (1.00, p < 0.05) over a 12-week period.
Association analysis between the C-1291G polymorphism in the promoter region of the adrenergic α2A receptor gene and polydipsia in schizophrenia
2009, Progress in Neuro-Psychopharmacology and Biological PsychiatryEffects of clonidine in schizophrenic patients with primary polydipsia: Three single case studies
2002, Progress in Neuro-Psychopharmacology and Biological PsychiatryTreatment of polydipsia and hyponatremia in psychiatric patients can clozapine be a new option
1995, NeuropsychopharmacologyPractical document on the management of hyponatremia in critically ill patients
2019, Medicina IntensivaManagement of hyponatremia
2014, CMAJ. Canadian Medical Association JournalCitation Excerpt :The effect of demeclocycline was nonsignificant in all analyses. There was also no significant difference in the number of episodes of serum sodium levels less than 125 mmol/L during the drug period (10 of 103 total sodium determinations) versus the placebo period.17 Given the small nature of this study and that the results showed no significant benefit over placebo, we do not recommend its use.