Brief reportUnderutilization of thrombolytic therapy in eligible women with acute myocardial infarction
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The Western Washington myocardial infarction registry and emergency department tissue plasminogen activator treatment trial
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Cited by (101)
Cardiogenic shock in women
2012, Interventional Cardiology ClinicsCitation Excerpt :Although a small randomized trial suggested some benefit with NO synthase inhibitors,65 a further study using tilarginine, an isoform nonselective NO synthase inhibitor (1-mg/kg bolus and 5-h infusion), did not reduce mortality among patients with refractory CS complicating MI despite an open infarct artery (in this study, only 26% of patients were women).2 Historically, perhaps in light of higher rates of contraindications among women, thrombolysis has been underused and door-to-needle times in those treated have been longer than for men.66,67 Despite this, rates of reperfusion between the genders have been comparable.68
Gender bias in women with myocardial infarction: Ten years after
2008, Medicina IntensivaWhy do women underestimate the risk of cardiac disease? A literature review
2007, Australian Critical CareCurrent topics (2005) in clinical cardiology: Cardiovascular disease in women
2006, Revista Espanola de CardiologiaExternal validity of randomised controlled trials: "to whom do the results of this trial apply?"
2005, LancetCitation Excerpt :A review of 41 US National Institutes of Health RCTs found an average exclusion rate of 73%.39 Strict eligibility criteria can limit the external validity of RCTs and result in lower rates of treatment in clinical practice,81 but the criteria are at least available for scrutiny, or should be (discussed below). More difficult is the extent to which trials with seemingly reasonable eligibility criteria end up with highly selected populations.
Outcomes of thrombolytic therapy for acute myocardial infarction in women
2004, Progress in Cardiovascular Diseases
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Dr. Maynard's address is: Division of Cardiology, RG-22, University of Washington, Seattle, Washington 98195.