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Clarithromycin induced torsade de pointes

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Abstract

Background

Clarithromycin is a commonly used macrolide antibiotic. It is known to cause QT prolongation. Medication induced QT prolongation is a major risk factor for the development of torsade de pointes.

Methods

A 79-year-old lady presented with frequent episodes of torsade de pointes following commencement of clarithromycin. This was noted to be in association with a prolongation of the QT interval.

Conclusion

Knowledge of medications which prolong the QT interval is important to minimize the risk of ventricular arrhythmias, which may lead to sudden death. This is essential in patients with a congenitally long QT interval.

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References

  1. Makkar R, Fromm B, Steinman R et al (1993) Female gender as a risk factor for torsade de pointes associated with cardiovascular drugs. JAMA 270:2590–2597

    Article  PubMed  CAS  Google Scholar 

  2. Hohnloser SH, Klingenheben T, Singh BN (1994) Amiodarone-associated proarrhythmic effects. A review with special reference to torsades de pointes tachycardia. Ann Intern Med 121:529–535

    PubMed  CAS  Google Scholar 

  3. Kurita T, Ohe T, Marui N, Aihara N, Takaki H, Kamakura S et al (1992) Bradycardia-induced abnormal QT prolongation in patients with complete atrioventricular block with torsade de pointes. Am J Cardiol 69:628–633

    Article  PubMed  CAS  Google Scholar 

  4. Irish Medicines Board, Pharmacovigilance Department (2006) http://www.imb.ie

  5. Gitler B, Berger LS, Buffa SD (1994) Torsades de pointes induced by erythromycin. Chest 105:368–372

    Article  PubMed  CAS  Google Scholar 

  6. Priori SG, Napolitano C, Schwartz PJ (1999) Low penetrance in the long-QT syndrome: clinical impact. Circulation 99:529–533

    PubMed  CAS  Google Scholar 

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Correspondence to C. Hensey.

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Hensey, C., Keane, D. Clarithromycin induced torsade de pointes. Ir J Med Sci 177, 67–68 (2008). https://doi.org/10.1007/s11845-007-0057-3

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  • DOI: https://doi.org/10.1007/s11845-007-0057-3

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