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Risk of coronary artery disease in patients with systemic sclerosis: a systematic review and meta-analysis

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Abstract

Several chronic inflammatory disorders, such as rheumatoid arthritis and systemic lupus erythematosus, have been shown to increase coronary artery disease (CAD) risk but the data on systemic sclerosis (SSc) is unclear. We conducted a systematic review and meta-analysis of observational studies that reported odds ratio, relative risk, hazard ratio, or standardized incidence ratio comparing CAD risk in patients with SSc versus non-SSc participants. Pooled risk ratio and 95 % confidence intervals were calculated using a random effect, generic inverse variance method. Four studies were identified and included in our data analysis. The pooled risk ratio of CAD in patients with SSc was 1.82 (95 % CI, 1.40 to 2.36). The statistical heterogeneity of this meta-analysis was moderate with an I 2 of 73 %. Our study demonstrated a statistically significant increased CAD risk among patients with SSc.

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We do not have any financial or nonfinancial potential conflicts of interest.

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Correspondence to Patompong Ungprasert.

Appendix

Appendix

Database: Ovid MEDLINE

  1. 1.

    exp Scleroderma, Limited/

  2. 2.

    exp Scleroderma, Diffuse/

  3. 3.

    exp Scleroderma, Systemic/

  4. 4.

    exp Scleroderma, Localized/

  5. 5.

    Scleroderma.mp.

  6. 6.

    systemic sclerosis.mp.

  7. 7.

    or/1-6

  8. 8.

    exp Coronary Disease/

  9. 9.

    coronary disease$.mp.

  10. 10.

    exp Coronary Artery Disease/

  11. 11.

    coronary arter$ disease$.mp.

  12. 12.

    exp Coronary Stenosis/

  13. 13.

    coronary stenos$.mp.

  14. 14.

    coronary atheroscleros$.mp.

  15. 15.

    coronary arterioscleros$.mp.

  16. 16.

    (coronary adj3 disease$).mp.

  17. 17.

    (coronary adj3 syndrome$).mp.

  18. 18.

    cad.mp.

  19. 19.

    exp Myocardial Infarction/

  20. 20.

    myocardial infarct$.mp.

  21. 21.

    exp Coronary Thrombosis/

  22. 22.

    coronary thrombos$.mp.

  23. 23.

    exp Angina, Unstable/

  24. 24.

    unstable angina.mp

  25. 25.

    (unstable adj3 angina).mp.

  26. 26.

    exp Angina, Stable/

  27. 27.

    stable angina.mp.

  28. 28.

    exp Angina Pectoris/

  29. 29.

    angina pectoris.mp.

  30. 30.

    acs.mp.

  31. 31.

    ami.mp.

  32. 32.

    or/8-31

  33. 33.

    7 and 32

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Ungprasert, P., Charoenpong, P., Ratanasrimetha, P. et al. Risk of coronary artery disease in patients with systemic sclerosis: a systematic review and meta-analysis. Clin Rheumatol 33, 1099–1104 (2014). https://doi.org/10.1007/s10067-014-2681-4

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  • DOI: https://doi.org/10.1007/s10067-014-2681-4

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