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Hepatic failure in a case of multiple myeloma-associated amyloidosis (k-AL)

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Abstract

We report a case of kappa-AL amyloidosis which rapidly developed hepatic failure in a 79-year-old Japanese female who was admitted to our hospital because of abdominal distension and loss of appetite. Laboratory examination revealed a marked deterioration of liver function with cholestasis and monoclonal gammapathy. At the time that the diagnosis of IgG-k type multiple myeloma was made, jaundice was advanced, with continuous gastrointestinal bleeding. The patient died of hepatic failure 2 weeks after admission. Needle biopsy of the liver revealed a diffuse, massive deposition of amyloid protein.

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Authors and Affiliations

  1. Second Department of Internal Medicine, Tottori University Faculty of Medicine, 683, Yonago, Japan

    Tetsuo Yamamoto & Hironaka Kawasaki

  2. Department of Gastroenterology, Hamada National Hospital, 697, Hamada, Japan

    Naoto Maeda

Authors
  1. Tetsuo Yamamoto
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  2. Naoto Maeda
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  3. Hironaka Kawasaki
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Yamamoto, T., Maeda, N. & Kawasaki, H. Hepatic failure in a case of multiple myeloma-associated amyloidosis (k-AL). J Gastroenterol 30, 393–397 (1995). https://doi.org/10.1007/BF02347517

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  • DOI: https://doi.org/10.1007/BF02347517

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