Summary
A healthy 19-year-old woman had vaginal intercourse on a single occasion with an HIV-1 positive male from Gambia. Two days later she developed an acute HIV infection presenting as a fulminant multisystem disease that lasted for 35 hospital days and included: immediate immunosuppression with extreme CD4+ lymphocytopenia and combined with CD8+ lymphocytosis, neutropenia and hypogammaglobulinemia; intermittent spiking fever; pneumonitis; hepatitis; changing skin rashes; peripheral neuropathy with myopathy, and panencephalitis. P24 antigen was detected by Western blot on day 23 and seroconversion was detected by ELISA on day 25. Cultured lymphocytes from peripheral blood and cerebrospinal fluid grew HIV-1.
Zusammenfassung
Eine gesunde 19-jährige Frau hatte einmaligen vaginalen Geschlechtsverkehr mit einem HIV-1-positiven Mann aus Gambia. Nach 2 Tagen entwickelte sich eine fulminante Multi-System-Erkrankung, die während des 35tägigen Krankenhausaufenthaltes bestehen blieb: sofortiges Auftreten einer Immunsuppression mit extremer CD4+-Lymphopenie, kombiniert mit CD8+-Lymphozytose, Neutropenie und Hypogammaglobulinämie, intermittierenden Fieberschüben, Pneumonitis, Hepatitis, wechselnden Exanthemen, peripherer Neuropathie und Myopathie sowie Panencephalitis. Der Western Blot für p24-Antigen war am Tag 23 positiv, die Serokonversion wurde am Tag 25 mit einem ELISA nachgewiesen. In Lymphozytenkulturen aus dem peripheren Blut und Liquor konnte HIV-1 angezüchtet werden.
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Ben-Galim, P., Shaked, Y., Garty, M. et al. Immediate immunosuppression caused by acute HIV-1 infection: A fulminant multisystemic disease 2 days post infection. Infection 24, 332–335 (1996). https://doi.org/10.1007/BF01743374
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DOI: https://doi.org/10.1007/BF01743374