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Fatal poisoning by MDMA (ecstasy) and MDEA: A case report

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Abstract

The first observation of lethal recreational use of MDMA (ecstasy) and MDEA in Italy is reported, together with extensive toxicological and histopathological documentation. Findings such as disseminated intravascular coagulation, rarely reported before, are colocated in the framework of the toxic syndrome for a better definition of criteria for forensic diagnosis.

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References

  1. Merck E (1914) Verfahren zur Darstellung von Alkyloxyaryldialyloxyaryl und Alkylenedioxyarlaminopropanen bzw. deren am Stickstoff monoalkylierten Derivaten. German Patent 274: 350

    Google Scholar 

  2. Yensen R, Di Leo FB, Rhead JC, Richards WA, Soskin RA (1976) MDA-assisted psychotherapy with neurotic outpatients: a pilot study. J Nerv Ment Dis 163:233–245

    PubMed  Google Scholar 

  3. Dowling J (1986) The psychological and physiological effects of MDMA on normal volunteers. J Psychoactive Drugs 18:335–340

    PubMed  Google Scholar 

  4. Greer G, Tolbert R (1986) Subjective reports of the effects of 3,4-methylenedioxymethamphetamine in a clinical setting. J Psychoactive Drugs 18:319–327

    PubMed  Google Scholar 

  5. Winstock A (1991) Chronic paranoid psychosis after misuse of MDMA. BMJ 302:1150–1151

    Google Scholar 

  6. Verebey K (1988) The complications of “Ecstasy” (MDMA). JAMA 259:1649–1650

    PubMed  Google Scholar 

  7. Greer G, Strassman R (1985) Information on ecstasy. Am J Psychiatry 142:1391

    PubMed  Google Scholar 

  8. Shafer J (1985) MDMA: psychedelic drug faces regulation. Psychol Today 19:68–69

    Google Scholar 

  9. Macchia T, Cioce AM, Mancinelli R (1995) MDMA ed altri amfetaminici: use ed abuso. Boll Farmacodip Alcol 18:16–41

    Google Scholar 

  10. Dowling G, McDonough E, Bost R (1987) “Eve” and “Ecstasy”. A report of five deaths associated with the use of MDEA and MDMA. JAMA 257:1615–1617

    PubMed  Google Scholar 

  11. Suarez RV, Riemersma R (1988) Ecstasy and sudden cardiac death. Am J Forensic Med Pathol 9:339–341

    PubMed  Google Scholar 

  12. Chadwick I, Curry P, Linsey A, Freemont AJ, Doran B (1991) Ecstasy, 3-4 methylenedioxymethamphetamine (MDMA): a fatality associated with coagulopathy and hyperthermia. J R Soc Med 84:371

    PubMed  Google Scholar 

  13. Rohrig TP, Prouty RW (1992) Tissue distribution of MDMA. J Anal Toxicol 16:52–53

    PubMed  Google Scholar 

  14. Campkin T, Davies U (1992) Another death from ecstasy. J R Soc Med 85:61

    Google Scholar 

  15. Screaton G, Singer M, Cairns H, Thrasher A, Sarner M, Cohen SL (1992) Hyperpyrexia and rhabdomyolysis after MDMA (“Ecstasy”) abuse. Lancet 339:677–678

    Google Scholar 

  16. Henry JA, Jeffreys K, Dawling S (1992) Toxicity and deaths from 3,4-methylenedioxymethamphetamine (“ecstasy”). Lancet 340:384–387

    PubMed  Google Scholar 

  17. Ferrara SD, Snenghi R, Giorgetti R, Zancaner S, Rossi A, Montisci M, Fenato F (1995) Amfetaminici ed analoghi di sintesi: disabilità e crimine. Boll Farmacodip Alcol 18:45–52

    Google Scholar 

  18. Cimbura G (1972) 3,4-methylenedioxyamphetamine (MDA): analytical and forensic aspects of fatal poisoning. J Forensic Sci 17:329–333

    PubMed  Google Scholar 

  19. Reed D, Cravey R, Sedgwick P (1972) A fatal case involving methylene dioxyamphetamine. Clin Toxicol 5:3–6

    PubMed  Google Scholar 

  20. Poklis A, Mackell M, Drake W (1979) Fatal intoxication from 3,4-methylenedioxyamphetamine. J Forensic Sci 24:70–75

    PubMed  Google Scholar 

  21. Lukaszewski T (1979) 3,4-Methylenedioxyamphetamine overdose. Clin Toxicol 15:405–409

    PubMed  Google Scholar 

  22. Nichols GR, Davis G, Corrigan C, Ransdell J (1990) Death associated with abuse of a designer drug. Kentucky Med J 88:600–603

    Google Scholar 

  23. Forrest ARW, Galloway JH, Marsh ID, Strachan GA, Clark JC (1994) A fatal overdose with 3,4-methylenedioxyamphetamine derivatives. Forensic Sci Int 64:57–59

    PubMed  Google Scholar 

  24. Fahal I, Sallomi D, Yaqoob M, Bell G (1992) Acute renal failure after ecstasy. BMJ 305:29

    Google Scholar 

  25. Brown C, Osterloh J (1987) Multiple severe complications from recreational ingestion of MDMA (“Ecstasy”). JAMA 258:780–781

    PubMed  Google Scholar 

  26. Pani L (1994) Terapia dell'overdose da ecstasy. Med Tossicodip 2:47

    Google Scholar 

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Fineschi, V., Masti, A. Fatal poisoning by MDMA (ecstasy) and MDEA: A case report. Int J Leg Med 108, 272–275 (1996). https://doi.org/10.1007/BF01369826

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  • DOI: https://doi.org/10.1007/BF01369826

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