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Radical prostatectomy as treatment for prostate-specific antigen-detected stage T1c prostate cancer

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Abstract

The use of serum prostate-specific antigen (PSA) measurement as a method for early detection of prostate cancer has increased the detection of clinically and pathologically localized prostate cancer. Clinical stage T1c was introduced to describe cancers discovered on prostate biopsy as a result of an abnormal serum PSA level without a palpable prostatic abnormality on digital rectal examination. The majority of men with stage T1c tumors have significant disease warranting treatment. We report the results of anatomic radical retropubic prostatectomy as therapy for PSA-detected stage T1c prostate cancer in 340 men treated at a single institution. In all, 17 men (5%) have had a recurrence with 2.3 ± 1.2 years of follow-up, 15 of whom have experienced an isolated biochemical PSA recurrence only. The overall actuarial biochemical PSA recurrence-free rate at 6 years is 87%, with pathologic stage being the best single indicator of the likelihood of progression. Although a longer period of follow-up is needed, this interim report suggests that these men can be cured by surgery at rates equal to or better than those of previously reported radical prostatectomy series.

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Authors and Affiliations

  1. The James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, 21287-2101, Baltimore, MD, USA

    Charles R. Pound, Patrick C. Walsh & Alan W. Partin

  2. Department of Pathology and The James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Jonathan I. Epstein

  3. Department of Pathology and Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Daniel W. Chan

Authors
  1. Charles R. Pound
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  2. Patrick C. Walsh
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  3. Jonathan I. Epstein
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  4. Daniel W. Chan
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  5. Alan W. Partin
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Additional information

Funding was provided by National Cancer Institute SPORE grant CA 58236

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Pound, C.R., Walsh, P.C., Epstein, J.I. et al. Radical prostatectomy as treatment for prostate-specific antigen-detected stage T1c prostate cancer. World J Urol 15, 373–377 (1997). https://doi.org/10.1007/BF01300186

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  • DOI: https://doi.org/10.1007/BF01300186

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