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The Behavioral Economics of Drug Dependence: Towards the Consilience of Economics and Behavioral Neuroscience

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Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 3))

Abstract

In this chapter, we review the research in this growing field by first discussing the concepts related to price and consumption (demand), its applications to the study of drug consumption and drug seeking, and the impact of other commodities on drug consumption. We then review the discounting of future commodities and events among the addicted, review the most recent research examining the neural correlates of discounting, and describe and review the new theory of addiction that results from that research. We conclude by addressing the next research steps that these advances engender.

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Abbreviations

fMRI:

Functional MRI

References

  • Ashton H, Stepney R, Thompson JW (1979) Self-titration by cigarette smokers. Br Med J 2:357–360

    Article  CAS  PubMed  Google Scholar 

  • Baum WM (2005) Understanding behaviorism: Behavior, culture, and evolution, 2nd edn. Blackwell Press, Malden, MA

    Google Scholar 

  • Baum WM, Rachlin H (1969) Choice as time allocation. J Exp Anal Behav 12:861–874

    Article  CAS  PubMed  Google Scholar 

  • Bechara A (2005) Decision making, impulse control and loss of willpower to resist drugs: A neurocognitive perspective. Nat Neurosci 8:1458–1463

    Article  CAS  PubMed  Google Scholar 

  • Bechara A, Damasio AR (2005) The somatic marker hypothesis: A neural theory of economic decision. Games Econ Behav 52:336–372

    Article  Google Scholar 

  • Becker JS, Murphy KM (1988) A theory of rational addiction. J Polit Econ 96:675–700

    Article  Google Scholar 

  • Benowitz NL, Peyton J III, Yu L, Talcott R, Hall S, Jones RT (1986) Reduced tar, nicotine, and carbon monoxide exposure while smoking ultralow- but not low-yield cigarettes. J Am Med Assoc 256:241–246

    Article  CAS  Google Scholar 

  • Bickel WK, DeGrandpre RJ (1995) Price and alternatives: Suggestions for drug policy from psychology. Int J Drug Policy 6:93–105

    Google Scholar 

  • Bickel WK, DeGrandpre RJ (1996a) Basic psychological science speaks to drug policy: Drug cost and competing reinforcement. In: Bickel WK, DeGrandpre RJ (eds) Drug policy and human nature: Psychological perspectives on the control, prevention and treatment of illicit drug use. Plenum, New York, pp 31–52

    Google Scholar 

  • Bickel WK, DeGrandpre RJ (1996b) Modeling drug abuse policy in the behavioral economics laboratory. In: Green L, Kagel JH (eds) Advances in behavioral economics, vol 3. Ablex, Norwood, NJ, pp 69–95

    Google Scholar 

  • Bickel WK, Madden GJ (1999) A comparison of measures of relative reinforcing efficacy and behavioral economics: Cigarettes and money in smokers. Behav Pharmacol 10:627–637

    Article  CAS  PubMed  Google Scholar 

  • Bickel WK, Marsch LA (2001) Toward a behavioral economic understanding of drug dependence: Delay discounting processes. Addiction 96:73–86

    Article  CAS  PubMed  Google Scholar 

  • Bickel WK, Higgins ST, Stitzer ML (1986) Choice of blind methadond dose increases by methadone maintenance patients. Drug Alcohol Depend 18:165–171

    Article  CAS  PubMed  Google Scholar 

  • Bickel WK, DeGrandpre RJ, Higgins ST, Hughes JR (1990) Behavioral economics of drug self-administration. I. Functional equivalence of response requirement and drug dose. Life Sci 47:1501–1510

    Article  CAS  PubMed  Google Scholar 

  • Bickel WK, DeGrandpre RJ, Hughes JR, Higgins ST (1991) Behavioral economics of drug self-administration. II. A unit-price analysis of cigarette smoking. J Exp Anal Behav 55:145–154

    Article  CAS  PubMed  Google Scholar 

  • Bickel WK, Hughes JR, DeGrandpre RJ, Higgins ST, Rizzuto P (1992) Behavioral economics of drug self-administration. IV. The effects of response requirement on the consumption of and interaction between concurrently available coffee and cigarettes. Psychopharmacology 107:211–216

    Article  CAS  PubMed  Google Scholar 

  • Bickel WK, DeGrandpre RJ, Higgins ST (1993) Behavioral economics: A novel experimental approach to the study of drug dependence. Drug Alcohol Depend 33:173–192

    Article  CAS  PubMed  Google Scholar 

  • Bickel WK, DeGrandpre RJ, Higgins ST (1995) The behavioral economics of concurrent drug reinforcers: A review and reanalysis of drug self-administration research. Psychopharmacology 118:250–259

    Article  CAS  PubMed  Google Scholar 

  • Bickel WK, Madden GJ, Petry NM (1998) The price of change: The behavioral economics of drug dependence. Behav Ther 29:545–565

    Article  Google Scholar 

  • Bickel WK, Odum AL, Madden GJ (1999) Impulsivity and cigarette smoking: Delay discounting in current, never, and ex-smokers. Psychopharmacology 146:447–454

    Article  CAS  PubMed  Google Scholar 

  • Bickel WK, Marsch LA, Carroll ME (2000) Deconstructing relative reinforcing efficacy and situating the measures of pharmacological reinforcement with behavioral economics: A theoretical proposal. Psychopharmacology 153:44–56

    Article  CAS  PubMed  Google Scholar 

  • Bickel WK, Miller ML, Yi R, Kowal BP, Lindquist DM, Pitcock JA (2007) Behavioral and neuroeconomics of drug addiction: Competing neural systems and temporal discounting processes. Drug Alcohol Depend 90(Suppl 1):s85–s91

    Article  PubMed  Google Scholar 

  • Bickel WK, Yi R, Kowal BP, Gatchalian KM (2008) Cigarette smokers discount past and future rewards symmetrically and more than controls: Is discounting a measure of impulsivity? Drug Alcohol Depend 96:256–262

    Article  PubMed  Google Scholar 

  • Boettiger CA, Mitchell JM, Tavares VC, Roberston M, Joslyn G, D’Esposito M, Fields HL (2007) Immediate reward bias in humans: Fronto-parietal networks and a role for the catechol-O-methyltransferase 158(Val/Val) genotype. J Neurosci 27:14383–14391

    Article  CAS  PubMed  Google Scholar 

  • Carroll ME (1987a) Self-administration of orally delivered phencyclidine and ethanol under concurrent fixed ratio schedules in rhesus monkeys. Psychopharmacology 93:1–7

    Article  CAS  PubMed  Google Scholar 

  • Carroll ME (1987b) Concurrent access to two concentrations of orally delivered phencyclidine: Effects of feeding conditions. J Exp Anal Behav 47:347–362

    Article  CAS  PubMed  Google Scholar 

  • Carroll ME, Meisch RA (1979) Concurrent etonitazene and water intake in rats: Role of taste, olfaction, and auditory stimuli. Psychopharmacology 64:1–7

    Article  CAS  PubMed  Google Scholar 

  • Carroll ME, Lac ST, Nygaard SL (1989) A concurrently available nondrug reinforcer prevents the acquisition or decreases the maintenance of cocaine-reinforced behavior. Psychopharmacology 97:23–29

    Article  CAS  PubMed  Google Scholar 

  • Carroll ME, Carmona GG, May SA (1991) Modifying drug reinforced behavior by altering the economic conditions of the drug and nondrug reinforcer. J Exp Anal Behav 56:361–376

    Article  CAS  PubMed  Google Scholar 

  • Castner SA, Goldman-Rakic PG (1997) Lateral prefrontal lesions in rhesus monkeys suppress sensitization of amphetamine-induced stereotyped behaviors. Soc Neurosci Abstr 23:1091

    Google Scholar 

  • Cestari V, Mele A, Oliverio A, Castellano C (1996) Amygdala lesions block the effect of cocaine on memory in mice. Brain Res 713:286–289

    Article  CAS  PubMed  Google Scholar 

  • Collette F, Salmon E, Van der Linden M, Chicherio C, Belleville S, Degueldre C, Delfiore G, Franck G (1999) Regional brain activity during tasks devoted to the central executive of working memory. Cogn Brain Res 7:411–417

    Article  CAS  Google Scholar 

  • Creighton DE, Lewis PH (1978) The effect of different cigarettes on human smoking patterns. In: Thornton RE (ed) Smoking behaviour: Physiological and psychological influences. Churchill Livingston, Edinburgh

    Google Scholar 

  • Dallery J, Raiff BR (2007) Delay discounting predicts cigarette smoking in a laboratory model of abstinence reinforcement. Psychopharmacology 190:485–496

    Article  CAS  PubMed  Google Scholar 

  • Damasio AR (1994) Descartes’ error: Emotion, reason, and the human brain. Grosset/Putnam, New York

    Google Scholar 

  • Damasio AR (1996) The somatic marker hypothesis and the possible functions of the prefrontal cortex. Philos Transact R Soc Biol Sci 351:1413–1420

    Article  CAS  Google Scholar 

  • Davison M, McCarthy D (1988) The matching law: A research review. Lawrence Erlbaum Associates, Publishers, Hillsdale, New Jersey

    Google Scholar 

  • de Wit H, Flory JD, Acheson A, McCloskey M, Manuck SB (2007) IQ and nonplanning impulsivity are independently associated with delay discounting in middle-aged adults. Pers Individ Dif 42:111–121

    Article  Google Scholar 

  • DeGrandpre RJ, Bickel WK, Hughes JR, Higgins ST (1992) Behavioral economics of drug self-administration. III. A reanalysis of the nicotine regulation hypothesis. Psychopharmacology 108:1–10

    Article  CAS  PubMed  Google Scholar 

  • DeNoble VJ, Svikis DS, Meisch RA (1982) Orally delivered pentobarbital as a reinforcer for rhesus monkeys with concurrent access to water: Effects of concentration, fixed-ratio size, and liquid positions. Pharmacol Biochem Behav 116:113–117

    Article  Google Scholar 

  • Dias R, Robbins TW, Roberts AC (1996a) Dissociation in prefrontal cortex of affective and attentional shifts. Nature 380:69–72

    Article  CAS  PubMed  Google Scholar 

  • Dias R, Robbins TW, Roberts AC (1996b) Primate analogue of the Wisconsin Card Sorting Test: Effects of excitotoxic lesions of the prefrontal cortex in the marmoset. Behav Neurosci 110:872–886

    Article  CAS  PubMed  Google Scholar 

  • Dom G, D’Haene P, Hulstijn W, Sabbe B (2006) Impulsivity in abstinent early- and late-onset alcoholics: Differences in self-report measures and a discounting task. Addiction 101:50–59

    Article  CAS  PubMed  Google Scholar 

  • Dworkin SI, Guerin GF, Goeders NE, Cherek DR, Lane JD, Smith JE (1984) Reinforcer interactions under concurrent schedules of food, water and intravenous morphine. Psychopharmacology 82:282–286

    Article  CAS  PubMed  Google Scholar 

  • Estle SJ, Green L, Myerson J, Holt DD (2007) Discounting of monetary and directly consumable rewards. Psychol Sci 18:58–63

    Article  PubMed  Google Scholar 

  • Evenden JL (1999) Varieties of impulsivity. Psychopharmacology 146:348–361

    Article  CAS  PubMed  Google Scholar 

  • Eysenck HJ (1993) The nature of impulsivity. In: McCown WG, Johnson J, Shure MB (eds) The impulsive client: Theory, research, and treatment. Am Psychol Assoc, Washington, DC, pp 57–70

    Chapter  Google Scholar 

  • Fey ET (1951) The performance of young schizophrenics and young normals on the Wisconsin Card Sorting Test. J Consult Clin Psychol 15:311–319

    CAS  Google Scholar 

  • Field M, Santarcangelo M, Sumnall H, Goudie A, Cole J (2006) Delay discounting and the behavioural economics of cigarette purchases in smokers: The effects of nicotine deprivation. Psychopharmacology 186:255–263

    Article  CAS  PubMed  Google Scholar 

  • Frith CD (1971) The effect of varying the nicotine content of cigarettes on human smoking behaviour. Psychopharmacologia 19:188–192

    Article  CAS  PubMed  Google Scholar 

  • Giordano LA, Bickel WK, Loewenstein G, Jacobs EA, Marsch LA, Badger GJ (2002) Mild opioid deprivation increases the degree that opioid-dependent outpatients discount delayed heroin and money. Psychopharmacology 163:174–182

    Article  CAS  PubMed  Google Scholar 

  • Glimcher PW, Rustichini A (2004) Neuroeconomics: The consilience of brain and decision. Science 306:447–452

    Article  CAS  PubMed  Google Scholar 

  • Goldberg SR (1973) Comparable behavior maintained under fixed-ratio and second-order schedules of food presentation, cocaine injections or d-amphetamine injection in the squirrel monkey. J Pharmacol Exp Ther 186:18–30

    CAS  PubMed  Google Scholar 

  • Goldberg SR, Hoffmeister F, Schlichting UU, Wuttke W (1971) A comparison of pentobarbital and cocaine self-administration in rhesus monkeys: Effects of dos and fixed ratio parameter. J Pharmacol Exp Ther 179:277–283

    CAS  PubMed  Google Scholar 

  • Goldfarb TL, Gritz ER, Jarvik ME, Stolerman JP (1976) Reaction to cigarettes as a function of nicotine and “tar”. Clin Pharmacol Ther 19:767–772

    CAS  PubMed  Google Scholar 

  • Gori GB (1976) Low risk cigarettes: A prescription. Science 194:1243–1246

    Article  CAS  PubMed  Google Scholar 

  • Gori GB, Lynch CJ (1978) Toward less hazardous cigarettes. J Am Med Assoc 240:1255–1259

    Article  CAS  Google Scholar 

  • Grant S, London ED, Newlin DB, Villemagne VL, Liu X, Contoreggi C, Phillips RL, Kimes AS, Margolin A (1996) Activation of memory circuits during cue-elicited cocaine craving. Proc Natl Acad Sci 83:12040–12045

    Article  Google Scholar 

  • Green L, Estle SJ (2003) Preference reversals with food and water reinforcers in rats. J Exp Anal Behav 79:233–244

    Article  PubMed  Google Scholar 

  • Green L, Freed D (1998) Behavioral economics. In: O’Donohue W (ed) Learning and behavior therapy. Allyn and Bacon, Boston, pp 274–300

    Google Scholar 

  • Green L, Myerson J (2004) A discounting framework for choice with delayed and probabilistic rewards. Psychological Bulletin 130:769–792

    Google Scholar 

  • Green L, Myerson J, McFadden E (1997) Rate of temporal discounting decreases with amount of reward. Mem Cogn 25:715–723

    Article  CAS  Google Scholar 

  • Griffiths RR, Brady JV, Bradford LD (1979) Predicting the abuse liability of drugs with animal drug self-administration procedures: Psychomotor stimulants and hallucinogens. In: Thompson T, Dews PB (eds) Advances in behavioral pharmacology, vol 2. Academic Press, New York, pp 163–208

    Google Scholar 

  • Griffiths RR, Wurster RM, Brady JV (1981) Choice between food and heroin: Effects of morphine, naloxone, and secobarbital. J Exp Anal Behav 35:335–351

    Article  CAS  PubMed  Google Scholar 

  • Griffiths RR, Henningfield JE, Bigelow GE (1982) Human cigarette smoking: Manipulation of number of puffs per bout, interbout interval and nicotine dose. J Pharmacol Exp Ther 220:256–265

    CAS  PubMed  Google Scholar 

  • Gust SW, Pickens RW (1982) Does cigarette nicotine yield affect puff volume? Clin Pharmacol Ther 32:418–422

    Article  CAS  PubMed  Google Scholar 

  • Haley JJ, Sepkovic DW, Hoffmann D, Wynder EL (1985) Cigarette smoking as a risk of cardiovascular disease. Part VI. Compensation with nicotine availability as a single variable. Clin Pharmacol Ther 38:164–170

    Article  CAS  PubMed  Google Scholar 

  • Hariri AR, Brown SM, Williamson DE, Flory JD, de Wit H, Manuck SB (2006) Preference for immediate over delayed rewards is associated with magnitude of ventral striatal activity. J Neurosci 26:13213–13217

    Article  CAS  PubMed  Google Scholar 

  • Harmer CJ, Phillips GD (1998) Enhanced appetitive conditioning following repeated pretreatment with d-amphetamine. Neuroscience 90:119–130

    Article  Google Scholar 

  • Harmer CJ, Hitchcott PK, Phillips GD (1997) Repeated d-amphetamine enhances stimulated mesoamydaloid dopamine transmission. Psychopharmacology 132:247–254

    Article  CAS  PubMed  Google Scholar 

  • Heil SH, Johnson MW, Higgins ST, Bickel WK (2006) Delay discounting in currently using and currently abstinent cocaine-dependent outpatients and non-drug-using matched controls. Addict Behav 31:1290–1294

    Article  PubMed  Google Scholar 

  • Hendelman W (2005) Atlas of functional neuroanatomy. CRC Press/Taylor and Francis Group/Routledge, Florence, KY, US

    Book  Google Scholar 

  • Henningfield JE, Griffiths RR (1980) Effects of ventilated cigarette holders on cigarette smoking by humans. Psychopharmacology 68:115–119

    Article  CAS  PubMed  Google Scholar 

  • Hill P, Marquardt H (1980) Plasma urine changes after smoking different brands of cigarettes. Clin Pharmacol Ther 27:652–658

    Article  CAS  PubMed  Google Scholar 

  • Hursh SR (1980) Economic concepts for the analysis of behavior. J Exp Anal Behav 34:219–238

    Article  CAS  PubMed  Google Scholar 

  • Hursh SR (1984) Behavioral economics. J Exp Anal Behav 42:435–452

    Article  CAS  PubMed  Google Scholar 

  • Hursh SR (1991) Behavioral economics of drug self-administration and drug abuse policy. J Exp Anal Behav 56:377–393

    Article  CAS  PubMed  Google Scholar 

  • Hursh SR, Bauman RA (1987) The behavioral analysis of demand. In: Green L, Kagel JH (eds) Advances in behavioral economics, vol 1. Ablex, Norwood, pp 117–165

    Google Scholar 

  • Hursh SR, Raslear TG, Shurleff D, Bauman R, Simmons L (1988) A cost-benefit analysis of demand for food. J Exp Anal Behav 50:419–440

    Article  CAS  PubMed  Google Scholar 

  • Hursh SR, Galuska CM, Winger G, Woods JH (2005) The economics of drug abuse: A quantitative assessment of drug demand. Mol Interv 5:20–28

    Article  PubMed  Google Scholar 

  • Iglauer C, Woods JH (1974) Concurrent performances: Reinforcement by different doses of intravenous cocaine in rhesus monkeys. J Exp Anal Behav 22:179–196

    Article  CAS  PubMed  Google Scholar 

  • Jacobs EA, Bickel WK (1999) Modeling drug consumption in the clinic using simulation procedures: Demand for heroin and cigarettes in opioid-dependent outpatients. Exp Clin Psychopharmacol 7:412–426

    Article  CAS  PubMed  Google Scholar 

  • Jarvik ME, Popek P, Schneider NG, Baer-Weiss V, Gritz ER (1978) Can cigarette size and nicotine content influence smoking and puffing rates? Psychopharmacology 58:303–306

    Article  CAS  PubMed  Google Scholar 

  • Jentsch JD, Taylor JR (1999) Impulsivity resulting from frontostriatal dysfunction in drug abuse: Implications for the control of behavior by reward-related stimuli. Psychopharmacology 146:373–390

    Article  CAS  PubMed  Google Scholar 

  • Johnson MW, Bickel WK (2002) Within-subject comparison of real and hypothetical money rewards in delay discounting. J Exp Anal Behav 77:129–146

    Article  PubMed  Google Scholar 

  • Johnson MW, Bickel WK (2003) The behavioral economics of cigarette smoking: The concurrent presence of a substitute and an independent reinforcer. Behav Pharmacol 14:137–144

    CAS  PubMed  Google Scholar 

  • Johnson MW, Bickel WK (2006) Replacing relative reinforcing efficacy with behavioral economic demand curves. J Exp Anal Behav 85:73–93

    Article  PubMed  Google Scholar 

  • Johnson MJ, Bickel WK, Kirshebaum AP (2004) Substitutes for tobacco smoking: A behavioral economic analysis of nicotine gum, denicotinized cigarettes, and nicotine-containing cigarettes. Drug Alcohol Depend 74:253–264

    Article  PubMed  Google Scholar 

  • Kable JW, Glimcher PW (2007) The neural correlates of subjective value during intertemporal choice. Nat Neurosci 10:1625–1633

    Article  CAS  PubMed  Google Scholar 

  • Killeen P (1992) The matching law. J Exp Anal Behav 17:489–495

    Article  Google Scholar 

  • Kirby KN (1997) Bidding on the future: Evidence against normative discounting of delayed rewards. J Exp Psychol Gen 126:54–70

    Article  Google Scholar 

  • Kirby KN, Petry NM, Bickel WK (1999) Heroin addicts have higher discount rates for delayed reward than non-drug-using controls. J Exp Psychol Gen 128:78–87

    Article  CAS  PubMed  Google Scholar 

  • Krishnan-Sarin S, Reynolds B, Duhig AM, Smith A, Liss T, McFetridge A, Cavallo DA, Carroll KM, Potenza MN (2007) Behavioral impulsivity predicts treatment outcome in a smoking cessation program for adolescent smokers. Drug Alcohol Depend 88:79–82

    Article  PubMed  Google Scholar 

  • Lea SEG, Roper TJ (1977) Demand for food on fixed-ratio schedules as a function of the quality of the function of concurrently available reinforcement. J Exp Anal Behav 27:371–380

    Article  CAS  PubMed  Google Scholar 

  • Lee EH, Ma YL (1995) Amphetamine enhances memory retention and facilitates norepinephrine release from the hippocampus in rats. Brain Res Bull 37:411–416

    Article  CAS  PubMed  Google Scholar 

  • Lemaire GA, Meisch RA (1984) Pentobarbital self-administration in rhesus monkeys: Drug concentration and fixed-ratio size interactions. J Exp Anal Behav 42:37–49

    Article  CAS  PubMed  Google Scholar 

  • LeMaire GA, Meisch RA (1985) Oral drug self-administration in rhesus monkeys: Interactions between drug amount and fixed-ratio size. J Exp Anal Behav 44:377–389

    Article  CAS  PubMed  Google Scholar 

  • MacKillop J, Murphy JG, Tidey JW, Kahler CW, Ray LA, Bickel WK (2009) Latent structure of facets of alcohol reinforcement from a behavioral economic demand curve. Psychopharmacology (Berl) 203:33–40

    Article  CAS  Google Scholar 

  • Madden GJ, Petry NM, Badger GJ, Bickel WK (1997) Impulsive and self-control choices in opioid-dependent patients and non-drug-using control participants: Drug and monetary rewards. Exp Clin Pharmacol 5:256–262

    CAS  Google Scholar 

  • Madden GJ, Bickel WK, Jacobs EA (1999) Discounting of delayed rewards in opioid-dependent outpatients: Exponential or hyperbolic discounting functions? Exp Clin Psychopharmacol 7:284–293

    Article  CAS  PubMed  Google Scholar 

  • Marquis MG, Moreton JE (1989) Effects of fixed ratio size and dose on phencyclidine self-administration by rats. Psychopharmacology 97:179–182

    Article  CAS  PubMed  Google Scholar 

  • Mazur JE (1987) An adjusting procedure for studying delayed reinforcement. In: Commons ML, Mazur JE, Nevin JA, Rachlin H (eds) Quantitative analysis of behavior (Vol. 5), The effects of delay and of intervening events on reinforcement value. Erlbaum, Mahwah, NJ, pp 55–73

    Google Scholar 

  • McClure SM, Laibson DI, Lowenstein G, Cohen JD (2004) Separate neural systems value immediate and delayed monetary rewards. Science 306:503–507

    Article  CAS  PubMed  Google Scholar 

  • McClure SM, Erikson KM, Laibson DI, Lowenstein G, Cohen JD (2007) Time discounting for primary rewards. J Neurosci 27:5796–5804

    Article  CAS  PubMed  Google Scholar 

  • McKetin R, Mattick RP (1998) Attention and memory in illicit amphetamine users: Comparison with non-drug-using controls. Drug Alcohol Depend 50:181–184

    Article  CAS  PubMed  Google Scholar 

  • McMorrow JJ, Foxx RM (1983) Nicotine’s role in smoking: An analysis of nicotine regulation. Psychol Bull 93:302–327

    Article  CAS  PubMed  Google Scholar 

  • Meil WM, See RF (1995) Excitotoxic lesions of the basolateral of amygdala attenuate the ability of cues to reinstate responding during withdrawal from self-administration. Soc Neurosci Abstr 21:1958

    Google Scholar 

  • Meisch RA, Lemaire GA (1988) Oral self-administration of pentobarbital by rhesus monkeys: Relative reinforcing effects under concurrent fixed-ratio schedules. J Exp Anal Behav 50:175–186

    Article  Google Scholar 

  • Meisch RA, Kliner DJ, Henningfield JE (1981) Pentobarbital drinking by rhesus monkeys: Establishment and maintenance of pentobarbital-reinforced behavior. J Pharmacol Exp Ther 217:114–119

    CAS  PubMed  Google Scholar 

  • Mello NK, Mendelson JH, Sellars ML, Kuehnle JC (1980a) Effects of heroin self-administration on cigarette smoking. Psychopharmacology 67:45–52

    Article  CAS  PubMed  Google Scholar 

  • Mello NK, Mendelson JH, Sellars ML, Kuehnle JC (1980b) Effects of alcohol and marijuana on tobacco smoking. Clin Pharmacol Ther 27:202–209

    Article  CAS  PubMed  Google Scholar 

  • Mello NK, Mendelson JH, Palmieri SL (1987) Cigarette smoking by women: Interactions with alcohol use. Psychopharmacology 93:8–15

    Article  CAS  PubMed  Google Scholar 

  • Mitchell SH (1999) Measures of impulsivity in cigarette smokers and non-smokers. Psychopharmacology 146:455–464

    Article  CAS  PubMed  Google Scholar 

  • Mitchell S (2004) Effects of short-term nicotine deprivation on decision-making: Delay, uncertainty and effort discounting. Nicotine Tob Res 6:819–828

    Article  CAS  PubMed  Google Scholar 

  • Mobini S, Grant G, Kass AE, Yeomans MR (2007) Relationships between functional and dysfunctional impulsivity, delay discounting and cognitive distortions. Pers Individ Dif 43:1517–1528

    Article  Google Scholar 

  • Monterosso J, Ainslie G (1999) Beyond discounting: Possible experimental models of impulse control. Psychopharmacology 146:339–347

    Article  CAS  PubMed  Google Scholar 

  • Moreton JE, Meisch RA, Stark L, Thompson J (1977) Ketamine self-administration by the rhesus monkey. J Pharmacol Exp Ther 203:303–309

    CAS  PubMed  Google Scholar 

  • Odum AL, Rainaud CP (2003) Discounting of delayed hypothetical money, alcohol, and food. Behav Processes 64:305–313

    Article  PubMed  Google Scholar 

  • Olausson P, Engel JA, Soderpalm B (1998) Behavioral sensitization and disinhibition after repeated amphetamine: Effect of serotonergic manipulations. Soc Neurosci Abstr 24:1735

    Google Scholar 

  • Parker JDA, Bagby RM, Webster CD (1993) Domains of the impulsivity construct: A factor analytic investigation. Pers Individ Dif 15:267–274

    Article  Google Scholar 

  • Paulus MP, Hozack N, Zauscher BE, Frank L, Brown GB, Braff DL, Schuckit MA (2002) Behavioral and functional neuroimaging evidence for prefrontal dysfunction in methamphetamine-dependent subjects. Neuropsychopharmacology 26:53–63

    Article  CAS  PubMed  Google Scholar 

  • Petry NM (2001) A behavioral economic analysis of polydrug abuse in alcoholics: Asymmetrical substitution of alcohol and cocaine. Drug Alcohol Depend 62:31–39

    Article  CAS  PubMed  Google Scholar 

  • Petry NM, Bickel WK (1998) Polydrug abuse in heroin addicts: A behavioral economic analysis. Addiction 93:321–335

    Article  CAS  PubMed  Google Scholar 

  • Petry NM, Casarella T (1999) Excessive discounting of delayed rewards in substance abusers with gambling problems. Drug Alcohol Depend 56:25–32

    Article  CAS  PubMed  Google Scholar 

  • Pickens R, Thompson J (1968) Cocaine-reinforced behavior in rats: Effects of reinforcement magnitude and fixed-ratio size. J Pharmacol Exp Ther 161:122–129

    CAS  PubMed  Google Scholar 

  • Pickens R, Muchow D, DeNoble VJ (1981) Methohexital-reinforced responding in rats: Effects of fixed-ratio size and injection dose. J Pharmacol Exp Ther 161:122–129

    Google Scholar 

  • Rachlin H, Raineri A, Cross D (1991) Subjective probability and delay. J Exp Anal Behav 55:233–244

    Article  CAS  PubMed  Google Scholar 

  • Reynolds B (2006) A review of delay-discounting research with humans: Relations to drug use and gambling. Behav Pharmacol 17:651–667

    Article  PubMed  Google Scholar 

  • Reynolds B, Ortengren A, Richards JB, de Wit H (2006) Dimensions of impulsive behavior: Personality and behavioral measures. Pers Individ Dif 40:305–315

    Article  Google Scholar 

  • Reynolds B, Penfold RB, Patak M (2008) Dimensions of impulsive behavior in adolescents: Laboratory behavioral assessments. Exp Clin Psychopharmacol 16:124–131

    Article  PubMed  Google Scholar 

  • Robbins TW (1990) The case for frontostriatal dysfunction in schizophrenia. Schizophr Bull 16:391–402

    CAS  PubMed  Google Scholar 

  • Rodefer JS, Carroll ME (1997) A comparison of progressive ratio schedules versus behavioral economic measures: Effect of an alternative reinforcer on the reinforcing efficacy of phencyclidine. Psychopharmacology 132:95–103

    Article  CAS  PubMed  Google Scholar 

  • Roehrs TA, Samson HH (1981) Ethanol reinforced behavior assessed with a concurrent schedule. Pharmacol Biochem Behav 15:539–544

    Article  CAS  PubMed  Google Scholar 

  • Rogers RD, Everitt BJ, Baldacchino A, Blackshaw AJ, Swainson R, Wynne K, Baker NB, Hunter J, Carthy T, Booker E, London M, Deakin JFW, Sahhakian BJ, Robbins TW (1999) Dissociable deficits in the decision-making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage of the prefrontal cortex, and tiptophan-depleted normal volunteers: Evidence for monoaminergic mechanisms. Neuropsychopharmacology 20:322–339

    Article  CAS  PubMed  Google Scholar 

  • Russel MA, Wilson C, Patel VA, Feyerbend C, Cole PV (1975) Plasma nicotine levels after smoking cigarettes with high, medium, and low nicotine yields. Br Med J 2:414–416

    Article  Google Scholar 

  • Russell MA, Wilson C, Patel VA, Cole PV, Feyerabend C (1973) Comparison of effect on tobacco consumption and carbon monoxide absorption of changing to high and low nicotine cigarettes. Br Med J 4:512–516

    Article  CAS  PubMed  Google Scholar 

  • Russell MA, Sutton SR, Feyerabend D, Saloojee Y (1980) Smokers’ response to shortened cigarettes: Dose reduction without dilution of tobacco smoke. Clin Pharmacol Ther 27:210–218

    Article  CAS  PubMed  Google Scholar 

  • Samson HH, Roehrs TA, Tolliver GA (1982) Ethanol reinforced responding in the rat: A concurrent analysis using sucrose as the alternate choice. Pharmacol Biochem Behav 17:333–339

    Article  CAS  PubMed  Google Scholar 

  • Samson HH, Tolliver GA, Roehrs TA (1983) Ethanol reinforced responding in the rat: Relation of ethanol introduction to later ethanol responding. Pharmacol Biochem Behav 18:895–900

    Article  CAS  PubMed  Google Scholar 

  • Seguin JR, Zelazo PD (2005) Executive function in early physical aggression. In: Tremblay RE, Hartup WW, Archer J (eds) Developmental origins of aggression. Guilford, New York, pp 307–329

    Google Scholar 

  • Shahan TA, Bickel WK, Madden GJ, Badger GJ (1999) Comparing the reinforcing efficacy of nicotine containing and de-nicotinized cigarettes: A behavioral economic analysis. Psychopharmacology 147:210–216

    Article  CAS  PubMed  Google Scholar 

  • Shahan TA, Odum AL, Bickel WK (2000) Nicotine gum as a substitute for cigarettes: A behavioral economic analysis. Behav Pharmacol 11:71–79

    CAS  PubMed  Google Scholar 

  • Shahan TA, Bickel WK, Badger GJ, Giordano LA (2001) Sensitivity of nicotine-containing and de-nicotinized cigarette consumption to alternative non-drug reinforcement: A behavioral economic analysis. Behav Pharmacol 12:277–284

    CAS  PubMed  Google Scholar 

  • Sinha R, Fuse T, Aubin LR, O’Malley SS (2000) Psychological stress, drug-related cues and cocaine craving. Psychopharmacology 152:140–148

    Article  CAS  PubMed  Google Scholar 

  • Skinner BF (1938) The behavior of organisms. Appleton-Century-Crofts, New York

    Google Scholar 

  • Skinner BF (1953) Science and human behavior. Macmillan, New York

    Google Scholar 

  • Skinner BF (1974) About behaviorism. Alfred A. Knopf, New York

    Google Scholar 

  • Spiga R, Martinetti MP, Meisch RA, Cowan K, Hursh S (2005) Methadone and nicotine self-administration in humans: A behavioral economic analysis. Psychopharmacology 178:223–231

    Article  CAS  PubMed  Google Scholar 

  • Stepney R (1981) Would a medium-nicotine, low-tar cigarette be less hazardous to health? Br Med J 283:1292–1296

    Article  CAS  Google Scholar 

  • Sumnall HR, Tyler E, Wagstaff GF, Cole JC (2004) A behavioural economic analysis of alcohol, amphetamine, cocaine and ecstasy purchases by polysubstance misusers. Drug Alcohol Depend 76:93–99

    Article  PubMed  Google Scholar 

  • Turner JAM, Sillett RW, Ball KP (1974) Some effects of changing to low-tar and low-nicotine cigarettes. Lancet II 2:737–739

    Article  CAS  Google Scholar 

  • Vuchinich RE, Simpson CA (1998) Hyperbolic temporal discounting in social drinkers and problem drinkers. Exp Clin Psychopharmacol 6:292–305

    Article  CAS  PubMed  Google Scholar 

  • Vuchinich RE, Tucker JA (1988) Contributions from behavioral theories of choice as a framework to an analysis of alcohol abuse. J Abnorm Psychol 97:181–195

    Article  CAS  PubMed  Google Scholar 

  • Wallace M (1956) Future time perspective in schizophrenia. J Abnorm Psychol 52:240–245

    Article  CAS  PubMed  Google Scholar 

  • Williams BA (1988) Reinforcement, choice, and response strength. In: Atkinson RC, Herrnstein RJ, Lindzey G, Luce RD (eds) Steven’s handbook of experimental psychology Vol 2. Learning and cognition vol 2. Wiley, New York, pp 167–244

    Google Scholar 

  • Wilson EO (1998) Consilience: The unity of knowledge. Alfred A. Knopf, New York

    Google Scholar 

  • Wittmann M, Paulus MP (2008) Decision making, impulsivity and time perception. Trends Cogn Sci 12:7–12

    Article  PubMed  Google Scholar 

  • Wittmann M, Leland DS, Paulus MP (2007) Time and decision making: Differential contribution of the posterior insular cortex and the striatum during a delay discounting task. Exp Brain Res 179:643–653

    Article  PubMed  Google Scholar 

  • Yi R, Gatchalian KM, Bickel WK (2006) Discounting of past outcomes. Exp Clin Psychopharmacol 14:311–317

    Article  PubMed  Google Scholar 

  • Yoon JH, Higgins ST, Heil SH, Sugarbaker RJ, Thomas CS, Badger GJ (2007) Delay discounting predicts postpartum relapse to cigarette smoking among pregnant women. Exp Clin Psychopharmacol 15:176–186

    Article  PubMed  Google Scholar 

  • Zacny JP, Stitzer ML (1988) Cigarette brand-switching: Effects of smoke exposure and smoking behavior. J Pharmacol Exp Ther 246:619–627

    CAS  PubMed  Google Scholar 

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Acknowledgments

The writing of this chapter was supported by National Institute on Drug Abuse Grants R37 DA 006526-18, R01 DA 11692-10, R01 DA022386-02, and R01 DA024080-01A1, Wilbur Mills Chair Endowment, and in part by the Arkansas Biosciences Institute, a partnership of scientists from Arkansas Children’s Hospital, Arkansas State University, the University of Arkansas-Division of Agriculture, the University of Arkansas, Fayetteville, and the University of Arkansas for Medical Sciences. The Arkansas Biosciences Institute is the major research component of the Tobacco Settlement Proceeds Act of 2000.

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Bickel, W.K., Yi, R., Mueller, E.T., Jones, B.A., Christensen, D.R. (2010). The Behavioral Economics of Drug Dependence: Towards the Consilience of Economics and Behavioral Neuroscience. In: Self, D., Staley Gottschalk, J. (eds) Behavioral Neuroscience of Drug Addiction. Current Topics in Behavioral Neurosciences, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2009_22

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