Balance in covariates and standardized differences in matched pairwise cohorts
| Variables | No. (%) of patients | Standardized difference | No. (%) of patients | Standardized difference | No. (%) of patients | Standardized difference | |||
|---|---|---|---|---|---|---|---|---|---|
| Warfarin n = 3654 | DOAC n = 3654 | Warfarin n = 3634 | No OAC n = 3634 | DOAC n = 8329 | No OAC n = 8329 | ||||
| Age > 80 yr | 2523 (69.1) | 2552 (69.8) | 0.02 | 2504 (68.9) | 2529 (69.6) | 0.01 | 5514 (66.2) | 5591 (67.1) | 0.02 |
| Sex, male | 1585 (43.4) | 1596 (43.7) | 0.01 | 1579 (43.5) | 1571 (43.2) | 0.004 | 3590 (43.1) | 3675 (44.1) | 0.02 |
| Atrial fibrillation | 2881 (78.9) | 2824 (77.3) | 0.04 | 2852 (78.5) | 2870 (79.0) | 0.01 | 6763 (81.2) | 6812 (81.8) | 0.02 |
| Cancer | 263 (7.2) | 257 (7.0) | 0.01 | 262 (7.2) | 265 (7.3) | 0.003 | 716 (8.6) | 711 (8.5) | 0.002 |
| CAD | 1712 (46.9) | 1730 (47.4) | 0.01 | 1703 (46.9) | 1741 (47.9) | 0.02 | 3586 (43.1) | 3732 (44.8) | 0.04 |
| COPD | 663 (18.1) | 677 (18.5) | 0.01 | 652 (17.9) | 685 (18.9) | 0.02 | 1509 (18.1) | 1455 (17.5) | 0.02 |
| CHF | 1685 (46.1) | 1668 (45.7) | 0.01 | 1661 (45.7) | 1641 (45.2) | 0.02 | 3015 (36.2) | 2901 (34.8) | 0.03 |
| Dementia | 1109 (30.4) | 1131 (31.0) | 0.01 | 1102 (30.3) | 1087 (29.9) | 0.01 | 2747 (33.0) | 2818 (33.8) | 0.02 |
| Diabetes | 1332 (36.5) | 1329 (36.4) | 0.002 | 1326 (36.5) | 1314 (35.2) | 0.01 | 2891 (34.7) | 2984 (35.8) | 0.02 |
| Hypertension | 2677 (73.3) | 2686 (73.5) | 0.01 | 2660 (73.2) | 2671 (73.5) | 0.01 | 6193 (74.4) | 6265 (75.2) | 0.02 |
| Liver failure | 47 (1.3) | 39 (1.1) | 0.02 | 47 (1.3) | 45 (1.2) | 0.004 | 99 (1.2) | 99 (1.2) | 0.00 |
| Multiple sclerosis | 9 (0.3) | 7 (0.2) | 0.01 | 8 (0.2) | 9 (0.3) | 0.01 | 21 (0.3) | 15 (0.2) | 0.02 |
| Parkinson | 125 (3.4) | 107 (2.9) | 0.03 | 126 (3.5) | 105 (2.9) | 0.03 | 368 (4.4) | 383 (4.6) | 0.01 |
| Renal failure | 849 (23.2) | 846 (23.2) | 0.002 | 846 (23.3) | 815 (22.4) | 0.02 | 1146 (13.8) | 1226 (14.7) | 0.03 |
| Seizure | 125 (3.4) | 104 (2.9) | 0.03 | 125 (3.4) | 104 (2.9) | 0.03 | 262 (3.2) | 269 (3.2) | 0.004 |
| Stroke (hemorrhagic) | 109 (3.0) | 106 (2.9) | 0.004 | 109 (3.0) | 112 (3.1) | 0.004 | 200 (2.4) | 199 (2.4) | 0.001 |
| Stroke or TIA (ischemic) | 811 (22.2) | 800 (21.9) | 0.01 | 798 (22.0) | 814 (22.4) | 0.01 | 1901 (22.8) | 1835 (22.0) | 0.02 |
| VTE | 682 (18.7) | 669 (18.3) | 0.01 | 852 (23.5) | 834 (23.0) | 0.02 | 831 (10.0) | 840 (10.1) | 0.004 |
| CCS ≥ 3 | 1286 (35.2) | 1273 (34.8) | 0.01 | 1276 (35.1) | 1299 (35.8) | 0.01 | 2534 (30.4) | 2542 (30.5) | 0.002 |
| Clopidogrel | 79 (2.2) | 59 (1.6) | 0.04 | 79 (2.2) | 76 (2.1) | 0.01 | 177 (2.1) | 247 (3.0) | 0.05 |
| Type of hospital | 0.02 | 0.03 | 0.005 | ||||||
| Small | 233 (6.4) | 176 (4.8) | 234 (6.4) | 177 (4.9) | 385 (4.6) | 363 (4.4) | |||
| Community | 2561 (70.1) | 2617 (71.6) | 2548 (70.2) | 2623 (72.2) | 6115 (73.4) | 6142 (73.4) | |||
| Academic | 860 (23.5) | 861 (23.6) | 852 (23.5) | 834 (23.0) | 1829 (22.0) | 1824 (21.9) | |||
Note: CAD = coronary artery disease, CCS = Charlson Comorbidity Score, COPD = chronic obstructive pulmonary disease, CHF = congestive heart failure, DOAC = direct oral anticoagulant, OAC = oral anticoagulation, TIA = transient ischemic attack, VTE = venous thromboembolism.