Unadjusted and adjusted* cause-specific hazard ratios for resuming oral anticoagulants versus not resuming oral anticoagulants†
| Index bleed type | Bleeding HR (95%CI) | Thrombosis HR (95%CI) | Mortality HR (95%CI) |
|---|---|---|---|
| All | |||
| Unadjusted | 1.98 (1.72–2.27) | 0.60 (0.50–0.72) | 0.50 (0.45–0.56) |
| Adjusted | 1.88 (1.64–2.17) | 0.60 (0.50–0.72) | 0.54 (0.48–0.60) |
| GI | |||
| Unadjusted | 1.99 (1.68–2.37) | 0.58 (0.46–0.74) | 0.49 (0.42–0.56) |
| Adjusted | 2.02 (1.69–2.40) | 0.56 (0.44–0.71) | 0.54 (0.47–0.62) |
| Intracranial | |||
| Unadjusted | 2.39 (1.50–3.80) | 0.72 (0.43–1.19) | 0.49 (0.34–0.71) |
| Adjusted | 2.20 (1.36–3.56) | 0.73 (0.44–1.23) | 0.54 (0.37–0.79) |
| Extracranial non-GI bleeding | |||
| Unadjusted | 1.52 (1.16–2.00) | 0.60 (0.41–0.88) | 0.51 (0.41–0.64) |
| Adjusted | 1.50 (1.15–1.98) | 0.60 (0.41–0.89) | 0.54 (0.43–0.68) |
Note: CI = confidence interval, GI = gastrointestinal, HR = hazard ratio, OAC = oral anticoagulant.
↵* Adjusted for age; sex; index bleed type; OAC at index bleed; antiplatelet or nonsteroidal anti-inflammatory therapy given 100 days preceding the index bleed; Charlson Comorbidity Index; and medical history of hypertension, diabetes, liver disease, renal disease, dementia or congestive heart failure.
↵† Not resuming OACs was the reference category.