Dose variables | Inclusion of patients prescribed blood pressure–lowering medication (n = 6468) in the definition of incident hypertension, HR (95% CI)* | Exclusion of patients prescribed blood pressure–lowering medication (n = 6468) from analyses, HR (95% CI)* |
---|---|---|
Daily dose category, mg | ||
Nonuse (Ref.) | 1 | 1 |
> 0–4.9 | 0.89 (0.82–0.97) | 1.51 (1.39–1.63) |
5.0–7.4 | 1.01 (0.93–1.10) | 1.70 (1.56–1.85) |
≥ 7.5 | 1.17 (1.11–1.24) | 1.79 (1.68–1.90) |
Overall cumulative dose category, mg | ||
Nonuse (Ref.) | 1 | 1 |
> 0–959.9 | 1.17 (1.13–1.22) | 1.31 (1.25–1.37) |
960–3054.9 | 1.16 (1.11–1.22) | 1.49 (1.41–1.58) |
≥ 3055 | 1.20 (1.16–1.25) | 1.85 (1.78–1.92) |
Note: CI = confidence interval, HR = hazard ratio, Ref. = reference category.
↵* Models were adjusted for age, index of multiple deprivation, non-oral glucocorticoid use (inhaled, nasal, intramuscular, intra-articular, topical or rectal), comorbidities (cardiovascular disease, chronic kidney disease and scleroderma) and type of chronic inflammatory disease.