Table 3:

Health outcomes in children at 3 years of age per interquartile range increase in the Frequency of Use Score for household use of cleaning products*

Outcome phenotypeOR (95% CI)Sex FUS
p value
Trend
p value
Overall sample population (IQRI = 13 points)
n = 2022
Boys (IQRI = 14 points)
n = 1047
Girls (IQRI = 13 points)
n = 975
Unadj.Adj.Unadj.Adj.Unadj.Adj.Unadj.Adj.
Recurrent wheeze1.45 (1.20–1.75)1.35 (1.11–1.64)1.27 (0.97–1.66)1.17 (0.89–1.55)1.78 (1.33–2.38)1.66 (1.22–2.25)0.070.090.0001
Recurrent wheeze and atopy1.65 (1.15–2.35)1.49 (1.02–2.16)1.37 (0.81–2.29)1.19 (0.98–1.05)2.18 (1.26–3.66)2.14 (1.17–3.86)0.180.180.003
Asthma diagnosis1.44 (1.16–1.78)1.37 (1.09–1.70)1.36 (1.00–1.85)1.32 (0.96–1.81)1.60 (1.14–2.23)1.48 (1.03–2.09)0.400.520.0004
Atopy1.10 (0.94–1.29)1.14 (0.96–1.35)1.03 (0.81–1.29)1.11 (0.87–1.41)1.20 (0.94–1.51)1.17 (0.90–1.50)0.340.290.12
  • Note: Adj. = adjusted, CI = confidence interval, FUS = Frequecy of Use Score, IQRI = interquartile range increase, OR = odds ratio, Unadj. = unadjusted.

  • * We derived all values using multivariable logistic regression models.

  • Models were adjusted for prenatal or early-life exposure to tobacco smoke, sex, child’s ethnicity, parental asthma history, household income, city/location, visible mould in the home and pet ownership.

  • For the sex-stratified analysis, we adjusted for all covariates except sex. The p value of the interaction term when included in the regression model for the overall sample is reported.

  • We used a 1-sided Cochran–Armitage test (unadjusted) to evaluate increasing trend, by continuous FUS score for each health outcome.