Outcome phenotype | OR (95% CI) | Sex^{‡} FUSp value | Trend^{¶}p value | ||||||
---|---|---|---|---|---|---|---|---|---|

Overall sample population (IQRI = 13 points)n = 2022 | Boys (IQRI = 14 points)n = 1047 | Girls (IQRI = 13 points)n = 975 | |||||||

Unadj. | Adj. | Unadj. | Adj. | Unadj. | Adj. | Unadj. | Adj. | ||

Recurrent wheeze | 1.45 (1.20–1.75) | 1.35 (1.11–1.64) | 1.27 (0.97–1.66) | 1.17 (0.89–1.55) | 1.78 (1.33–2.38) | 1.66 (1.22–2.25) | 0.07 | 0.09 | 0.0001 |

Recurrent wheeze and atopy | 1.65 (1.15–2.35) | 1.49 (1.02–2.16) | 1.37 (0.81–2.29) | 1.19 (0.98–1.05) | 2.18 (1.26–3.66) | 2.14 (1.17–3.86) | 0.18 | 0.18 | 0.003 |

Asthma diagnosis | 1.44 (1.16–1.78) | 1.37 (1.09–1.70) | 1.36 (1.00–1.85) | 1.32 (0.96–1.81) | 1.60 (1.14–2.23) | 1.48 (1.03–2.09) | 0.40 | 0.52 | 0.0004 |

Atopy | 1.10 (0.94–1.29) | 1.14 (0.96–1.35) | 1.03 (0.81–1.29) | 1.11 (0.87–1.41) | 1.20 (0.94–1.51) | 1.17 (0.90–1.50) | 0.34 | 0.29 | 0.12 |

Note: Adj. = adjusted, CI = confidence interval, FUS = Frequecy of Use Score, IQRI = interquartile range increase, OR = odds ratio, Unadj. = unadjusted.

↵* We derived all values using multivariable logistic regression models.

↵† Models were adjusted for prenatal or early-life exposure to tobacco smoke, sex, child’s ethnicity, parental asthma history, household income, city/location, visible mould in the home and pet ownership.

↵‡ For the sex-stratified analysis, we adjusted for all covariates except sex. The

*p*value of the interaction term when included in the regression model for the overall sample is reported.↵¶ We used a 1-sided Cochran–Armitage test (unadjusted) to evaluate increasing trend, by continuous FUS score for each health outcome.