Heart disease and risk of hospital admission for allopurinol-associated severe cutaneous adverse reactions, by presence of chronic kidney disease and initial allopurinol dosage
| Variable | Initial allopurinol dosage | (+) Heart disease | (−) Heart disease | ||
|---|---|---|---|---|---|
| Risk of hospital admission for allopurinol-associated severe cutaneous adverse reactions per 1000 patients (95% CI) | Multivariable relative risk* (95% CI) | Risk of hospital admission for allopurinol-associated severe cutaneous adverse reactions per 1000 patients (95% CI) | Multivariable relative risk* (95% CI) | ||
| (+) Chronic kidney disease | > 100 mg/d | 4.45 (2.44–7.47) | 11.13 (4.66–26.58) | 1.41 (0.52–3.06) | 4.52 (1.60–12.78) |
| ≤100 mg/d | 1.00 (0.27–2.56) | 2.28 (0.68–7.58) | 0.45 (0.05–1.61) | 1.24 (0.27–5.80) | |
| (−) Chronic kidney disease | > 100 mg/d | 1.29 (0.75–2.06) | 3.44 (1.52–7.81) | 0.79 (0.58–1.04) | 3.06 (1.50–6.23) |
| ≤100 mg/d | 1.02 (0.44–2.01) | 2.41 (0.92–6.64) | 0.29 (0.13–0.55) | 1.00 (Ref.) | |
Note: CI = confidence interval, Ref. = reference category
↵* Adjusted for age, sex, region, diabetes, diuretics and gout.