Table 2:

Hazard ratios for major adverse cardiovascular events, by predicted lean body mass index quartiles

Lean BMI quartile	No. of events	Incidence rate, %	HR (95% CI)
Lean BMI quartile	No. of events	Incidence rate, %	Model 1^*	Model 2^†	Model 3^‡	Model 4^§
1	464	18.3	Ref.	Ref.	Ref.	Ref.
2	429	16.9	0.91 (0.79–1.03)	0.93 (0.81–1.06)	0.93 (0.81–1.06)	0.87 (0.75–1.01)
3	435	17.2	0.919 (0.81–1.05)	0.96 (0.84–1.10)	0.98 (0.86–1.12)	0.86 (0.72–1.03)
4	473	18.7	1.02 (0.90–1.16)	1.14 (1.00–1.30)	1.14 (1.00–1.31)	0.92 (0.72–1.17)
p value for trend			0.75	0.06	0.05	0.3

Note: BMI = body mass index, CI = confidence interval, HR = hazard ratio, Ref. = reference.
↵* Unadjusted.
↵† Adjusted for age, ethnicity and sex.
↵‡ Adjusted for age, ethnicity, sex, treatment group, hypertension, hyperlipidemia, smoking, previous cardiovascular disease, previous heart failure, height and fasting blood glucose.
↵§ Adjusted using characteristics for Model 3 by adding fat mass index.