Box 1: Absolute outcome comparisons among adults aged 65 years and older receiving SD-TIV and HD-TIV
OutcomeSD-TIVHD-TIV
Laboratory-confirmed influenza11.9%1.4%
Hospital admissions for laboratory-confirmed influenza21.10 per 10 000 person-weeks0.86 per 10 000 person-weeks
Post-influenza death30.038 per 10 000 person-weeks0.028 per 10 000 person-weeks
Mild adverse events*429.4%34.3%

  • Note: HD-TIV = high-dose trivalent inactivated influenza vaccine,

  • SD-TIV = standard-dose trivalent inactivated influenza vaccine.

  • ↵* For example, fever, headache, malaise and myalgia.