Table 3:

Percentage change* and absolute change in serum creatinine concentration: methylprednisolone versus placebo

VariableMethylprednisolone
n = 3647
Placebo
n = 3639
Adjusted mean difference (95% CI)
Median (IQR)Mean ± SDMedian (IQR)Mean ± SD
Percentage change in serum creatinine*22 (4 to 46)38 ± 7820 (1 to 46)38 ± 820.02 (−3.7 to 3.7)
Absolute change in serum creatinine, mg/dL0.20 (0.03 to 0.44)0.35 ± 0.600.20 (0.01 to 0.44)0.36 ± 0.65−0.01 (−0.04 to 0.02)
  • Note: CI = confidence interval, IQR = interquartile range (25th, 75th percentiles), SD = standard deviation.

  • * Percentage change in serum creatinine: [(peak postoperative serum creatinine within 14 days after surgery – prerandomization serum creatinine)/prerandomization serum creatinine] × 100%.

  • Absolute change in serum creatinine: peak postoperative serum creatinine within 14 days after surgery – prerandomization serum creatinine.

  • Adjusted for 10 prespecified covariates: age (yr); sex; left ventricular function < 50%; diabetes; preoperative estimated glomerular filtration rate < 60 mL/min/1.73m2; prerandomization use of angiotensin converting enzyme inhibitors or angiotensin receptor blockers, statins, or diuretics; surgery type (isolated valve [referent], isolated coronary artery bypass grafting [CABG], CABG and valve, or other); and evidence of nonelective surgery (defined as preoperative use of inotropes or vasopressors, preoperative use of an intra-aortic balloon pump or ventricular assist device, or evidence of myocardial infarction in the 30 days before surgery).