Association between statin dose and 1-year admission to hospital for cardiovascular events in older Ontario residents living in long-term care facilities who were prescribed statins, overall and by subgroup*
Analysis | No. of matched pairs analyzed | One-year cumulative incidence of admission to hospital for cardiovascular events, % | Risk difference in 1-yr cumulative incidence, % (95% CI) | HR† (95% CI) | |
---|---|---|---|---|---|
Residents taking intensive-dose statins | Residents taking moderate-dose statins | ||||
Primary analysis, all matched pairs | 4577 | 11.41 | 11.45 | −0.04 (−1.34 to 1.26) | 0.99 (0.88 to 1.12) |
Stratified analysis | |||||
Sex | |||||
Female | 2776 | 10.34 | 10.77 | −0.43 (−2.05 to 1.19) | 0.96 (0.82 to 1.12) |
Male | 1801 | 13.05 | 12.49 | 0.56 (−1.62 to 2.74) | 1.04 (0.87 to 1.25) |
History of atherosclerotic-related admission to hospital | |||||
No | 1560 | 8.08 | 8.21 | −0.13 (−2.06 to 1.80) | 0.98 (0.77 to 1.25) |
Yes | 3017 | 13.13 | 13.13 | 0.00 (−1.69 to 1.69) | 1.00 (0.87 to 1.15) |
Frailty status | |||||
Prefrail or not frail | 2119 | 12.13 | 12.41 | −0.28 (−2.26 to 1.70) | 0.98 (0.82 to 1.16) |
Frail | 2458 | 10.78 | 10.62 | 0.16 (−1.57 to 1.89) | 1.01 (0.85 to 1.20) |