Table 2:

Trends in age-standardized mortality rates: 1974–2015

Disease	AAPC (95% CI) (1974–2015)	Joinpoint trend 1		Joinpoint trend 2		Joinpoint trend 3
Disease	AAPC (95% CI) (1974–2015)	Years	AAPC (95% CI)	Years	AAPC (95% CI)	Years	AAPC (95% CI)	AAPC (95% CI) (1st breakpoint to 2015)^*
Communicable, maternal, perinatal and nutritional conditions	−3.5 (−5.2 to 1.8)^†	1974–1988	1.6 (0.2 to 3.1)^†	1988–1992	−22.2 (−34.0 to −8.2)^†	1992–2015	−3.0 (−4.2 to −1.7)^†	−6.7 (−9.3 to −4.1)^†
Infectious and parasitic diseases	−5.0 (−6.7 to −3.3)^†	1974–1989	−3.7 (−5.1 to −2.2)^†	1989–1994	−9.1 (−20.1 to 3.5)	1994–2015	−5.0 (−6.3 to −3.6)^†	−6.5 (−9.6 to −3.4)^†
Maternal conditions	–	–	–	–	–	–	–	–
Neonatal conditions	−1.9 (−6.4 to 2.8)	1974–1988	6.8 (3.3 to 10.6)^†	1988–1991	−40.8 (−68.0 to 9.5)	1991–2015	−0.6 (−3.0 to 1.9)	−8.7 (−22.1 to 7.0)
Respiratory infections	−1.2 (−5.3 to 3.1)	1974–1987	3.8 (−1.8 to 9.8)	1987–1993	−21.4 (−39.0 to 1.2)	1993–2015	2.2 (−0.8 to 5.2)	−6.1 (−12.8 to 0.4)
Chronic noncommunicable diseases	−1.3 (−1.6 to −0.9)^†	1974–1995	0.3 (0.0 to 0.7)^†	1995–2004	−4.7 (−5.9 to −3.5)^†	2004–2015	−1.5 (−2.2 to −0.7)^†	−2.9 (−3.5 to −2.3)^†
Cancer	−0.7 (−0.9 to −0.5)^†	1974–1991	0.4 (−0.0 to 0.9)	1991–2015	−1.5 (−1.7 to −1.3)^†			−1.5 (−1.7 to −1.3)^†
Cardio-cerebrovascular disease	−1.0 (−1.7 to −0.2)^†	1974–1998	0.8 (0.3 to 1.2)^†	1998–2003	−9.2 (−14.1 to −4.1)^†	2003–2015	−0.8 (−1.8 to 0.2)	−3.3 (−4.4 to −2.2)^†
Congenital anomalies	−1.5 (−4.2 to 1.3)	1974–1988	4.2 (1.1 to 7.5)^†	1988–1993	−18.4 (−32.9 to −0.8)^†	1993–2015	−0.8 (−3.2 to 1.6)	−5.5 (−9.1 to −1.7)^†
Diabetes mellitus	1.7 (0.9 to 2.4)^†	1974–2005	3.2 (2.5 to 3.9)^†	2005–2015	−2.9 (−5.1 to −0.7)^†			−2.9 (−5.1 to −0.7)^†
Digestive diseases	−2.7 (−3.6 to −1.8)^†	1974–1990	−0.4 (−1.5 to 0.7)	1990–1998	−7.6 (−11.0 to −4.1)^†	1998–2015	−2.5 (−3.4 to −1.5)^†	−4.7 (−6.8 to −2.6)^†
Endocrine, blood, immune disorders	−0.5 (−5.6 to 4.9)	1974–2001	0.5 (−1.1 to 2.2)	2001–2005	−17.2 (−50.6 to 38.7)	2005–2015	4.1 (−3.1 to 11.9)	−3.6 (−15.9 to 10.4)
Genitourinary diseases	−2.7 (−5.1 to −0.3)^†	1974–1995	−0.5 (−1.4 to 0.4)	1995–1998	−15.6 (−39.5 to 18.0)	1998–2015	−2.9 (−4.2 to −1.6)^†	−5.4 (−7.2 to −3.5)^†
Mental and substance use disorders	−0.6 (−3.4 to 2.3)	1974–2002	−1.2 (−2.1 to −0.3)^†	2002–2013	−4.2 (−8.9 to 0.6)	2013–2015	33.7 (−21.7 to 128.2)	0.5 (−5.6 to 7.1)
Musculoskeletal diseases	−3.5 (−4.1 to −2.8)^†	1974–2015	−3.5 (−4.1 to −2.8)^†					–
Neurological conditions	0.1 (−1.8 to 2.1)	1974–1999	5.4 (4.1 to 6.6)^†	1999–2004	−21.0 (−30.8 to −9.7)^†	2004–2015	−0.7 (−4.0 to 2.7)	−7,1 (−10.0 to −4.1)^†
Oral conditions	–	–	–	–	–	–	–	–
Respiratory diseases	−3.5 (−4.2 to −2.7)^†	1974–1993	0.4 (−0.4 to 1.2)	1993–2005	−8.4 (−10.0 to −6.8)^†			−8.4 (−10.0 to −6.8)^†
Sense organ diseases	–	–	–	–	–	–	–	–
Skin diseases	–	–	–	–	–	–	–	–
Injuries	−3.1 (−3.7 to −2.4)^†	1974–1994	−0.6 (−1.5 to 0.3)	1994–2015	−5.4 (−6.3 to −4.5)^†			−5.4 (−6.3 to −4.5)^†

Note: AAPC = average annual percentage change, CI = confidence interval, − = the number is too small to calculate AAPC values.
↵* 1st breakpoint corresponds to the last year of joinpoint trend 1 and the first year of joinpoint trend 2.
↵† AAPC value is significantly different from 0 at α = 0.05.