Table 4:

Diagnostic accuracy of the clinical chemistry score with high-sensitivity cardiac troponin T for myocardial infarction or death at 30 days after presentation to the emergency department, by cohort

ScoreSensitivity, % (95% CI)Specificity, % (95% CI)Negative predictive value, % (95% CI)Positive predictive value, % (95% CI)Negative likelihood ratio (95% CI)Positive likelihood ratio (95% CI)
Hamilton cohort, n = 1092
 0100 (97.9–100)9.6 (7.8–11.7)100 (95.0–100)17.6 (17.3–17.9)0 (0–0.22)1.11 (1.07–1.13)
 198.9 (96.0–99.9)30.5 (27.5–33.6)99.3 (97.2–99.8)21.6 (20.8–22.4)0.04 (0.01–0.13)1.42 (1.36–1.49)
 547.5 (39.9–55.1)90.4 (88.3–92.2)89.9 (88.5–91.1)48.8 (24.6–55.1)0.58 (0.50–0.66)4.9 (3.8–6.3)
Brisbane cohort, n = 795
 0100 (92.7–100)21.7 (18.8–24.8)100 (97.7–100)7.7 (5.8–10.1)0 (0–0.34)1.28 (1.16–1.32)
 198 (89.1–99.9)55.1 (51.4–58.7)99.8 (98.7–100)12.5 (9.4–16.3)0.04 (0.01–0.19)2.18 (1.96–2.38)
 551 (36.3–65.6)97.2 (95.7–98.2)96.8 (95.3–97.9)54.3 (39.0–69.1)0.50 (0.37–0.64)18.1 (10.9–29.6)
Christchurch cohort, n = 946
 0100 (97.6–100)6.0 (4.3–7.9)100 (88.0–100)24.9 (22.1–27.9)0 (0–0.28)1.06 (1.04–1.08)
 197.3 (94.3–99.0)31.6 (28.2–35.2)97.4 (94.5–99.1)30.8 (27.4–34.3)0.08 (0.04–0.18)1.42 (1.35–1.50)
 549.8 (43.1–56.5)95.3 (93.5–96.7)85.9 (83.3–88.2)76.7 (69.0–83.3)0.53 (0.46–0.60)10.6 (7.4–15.0)
Hamburg cohort, n = 1412
 099.6 (98.0–100)13.2 (11.4–15.3)99.3 (96.3–100)21.8 (19.6–24.2)0.03 (0–0.15)1.15 (1.12–1.18)
 196.0 (93.0–97.8)34.7 (32.0–37.5)97.3 (95.2–98.5)26.3 (23.7–29.1)0.11 (0.06–0.20)1.47 (1.40–1.54)
 543.8 (38.1–49.7)93.9 (92.4–95.2)87.3 (85.3–89.1)63.7 (56.6–70.2)0.60 (0.53–0.66)7.2 (5.5–9.4)
  • Note: CI = confidence interval.