Table 3:

Diagnostic accuracy of the clinical chemistry score with high-sensitivity cardiac troponin I for myocardial infarction or death at 30 days after presentation to the emergency department, by cohort

ScoreSensitivity, % (95% CI)Specificity, % (95% CI)Negative predictive value, % (95% CI)Positive predictive value, % (95% CI)Negative likelihood ratio (95% CI)Positive likelihood ratio (95% CI)
Hamilton cohort, n = 1092
 0100 (97.9–100)10.0 (8.1–12.1)100 (95.1–100)17.7 (17.4–18)0 (0–0.21)1.11 (1.08–1.13)
 198.9 (96.0–99.8)32.5 (29.4–35.6)99.3 (97.4–99.8)22.1 (21.3–22.9)0.03 (0.01–0.12)1.46 (1.40–1.54)
 544.6 (37.1–52.3)95.6 (94.1–96.9)89.9 (88.6–91.1)66.4 (58.3–73.6)0.58 (0.50–0.65)10.2 (7.2–14.4)
Brisbane cohort, n = 795
 0100 (92.7–100)19.7 (16.9–22.7)100 (97.5–100)7.6 (5.6–9.90 (0–0.37)1.25 (1.13–1.29)
 1100 (92.7–100)54.6 (50–9–58.2)100 (99.1–100)12.6 (9.5–16.4)0 (0–0.13)2.20 (1.97–2.37)
 553.1 (38.3–67.5)98.0 (96.7–98.9)96.9 (95.5–98.1)63.4 (46.9–77.9)0.48 (0.43–0.61)26.4 (15.0–45.9)
Christchurch cohort, n = 946
 0100 (97.6–100)4.4 (3.1–6.2)100 (84.2–100)24.6 (21.9–27.5)0 (0–0.38)1.05 (1.02–1.06)
 199.6 (97.5–100)25.7 (22.5–29.0)99.5 (97–100)29.5 (26.3–32.9)0.02 (0–0.10)1.34 (1.28–1.40)
 556.4 (49.7–63.0)97.9 (96.6–98.8)87.8 (85.3–90.0)89.4 (83.2–94.0)0.44 (0.38–0.51)27.1 (16.4–45.2)
Hamburg cohort, n = 1412
 0100 (98.6–100)9.5 (7.9–11.4)100 (96.6–100)21.2 (19.0–23.5)0 (0–0.14)1.11 (1.08–1.13)
 199.3 (97.4–99.8)29.1 (26.6–31.8)99.4 (97.8–99.8)25.4 (22.9–28.1)0.02 (0.01–0.09)1.40 (1.35–1.46)
 545.7 (39.9–51.5)95.7 (94.3–96.7)87.9 (85.9–89.6)72.0 (64.9–78.1)0.57 (0.51–0.63)10.6 (7.8–14.3)
  • Note: CI = confidence interval.