Table 5:

Allergic reactions induced by nonsteroidal anti-inflammatory drugs47

PathophysiologyReaction typeUnderlying conditionSymptoms
COX-1 inhibition (nonimmune)NERDAsthma, rhinitis, sinusitis, polypsUpper and lower respiratory
NECDChronic urticariaCutaneous
NIUACutaneous
IgE-mediated (immune-mediated)SNIUAACutaneous or anaphylaxis
  • Note: COX-1 = cyclooxygenase-1, IgE = immunoglobulin E, NECD = NSAID-exacerbated cutaneous disease, NERD = NSAID-exacerbated respiratory disease, NIUA = NSAID-induced urticaria/angioedema, NSAID = nonsteroidal anti-inflammatory drug, SNIUAA = single-NSAID–induced urticaria/angioedema or anaphylaxis.