Number of poisoning calls before and after reformulation
| Drug reported in poisoning call | No. of quarterly calls before reformulation, median (IQR) | Unadjusted for oral morphine equivalents (mg) dispensed | Adjusted for oral morphine equivalents (mg) dispensed | ||||
|---|---|---|---|---|---|---|---|
| Quarterly trend before reformulation | Level shift | Change in trend after reformulation | Quarterly trend before reformulation | Level shift | Change in trend after reformulation | ||
| IRR (95% CI) | IRR (95% CI) | IRR (95% CI) | IRR (95% CI) | IRR (95% CI) | IRR (95% CI) | ||
| Oxycodone, oral | 90 (85–101) | 1.02 (0.97 to 1.06) | 1.22 (0.99 to 1.49) | 0.98 (0.94 to 1.03) | 1.03 (0.98 to 1.08) | 1.31 (1.05 to 1.64) | 1.01 (0.96 to 1.06) |
| Oxycodone, injected | 8 (7–9) | 1.01 (0.88 to 1.16) | 0.99 (0.47 to 2.08) | 0.91 (0.77 to 1.08) | 1.02 (0.89 to 1.17) | 1.07 (0.51 to 2.22) | 0.93 (0.79 to 1.10) |
| Oxycodone/naloxone | 8 (6–13) | 1.03 (0.90 to 1.18) | 1.77 (1.00 to 3.13) | 1.04 (0.90 to 1.20) | 0.87 (0.77 to 1.00) | 1.52 (0.87 to 2.65) | 1.16 (1.01 to 1.34) |
| Morphine | 13 (8–16) | 0.93 (0.84 to 1.03) | 0.89 (0.50 to 1.60) | 1.05 (0.93 to 1.19) | 0.96 (0.87 to 1.06) | 0.82 (0.45 to 1.47) | 1.04 (0.92 to 1.18) |
| Other opioids* | 112 (101–117) | 0.99 (0.96 to 1.03) | 1.08 (0.90 to 1.29) | 1.02 (0.98 to 1.07) | 0.99 (0.96 to 1.03) | 1.05 (0.87 to 1.27) | 0.96 (0.92 to 1.00) |
| Heroin | 7 (4–8) | 1.00 (0.83 to 1.20) | 0.90 (0.36 to 2.25) | 1.08 (0.87 to 1.32) | NA | NA | NA |
Note: CI = confidence interval, IQR = interquartile range, IRR = incidence rate ratio, NA = not applicable.
↵* Excludes codeine combination products.