Adverse effects and requirement for breakthrough acetaminophen for participants who took at least 1 dose of the study drug
| Outcome | Study medication; no. (%) of participants* | p value† | |
|---|---|---|---|
| Oral morphine n = 65 | Ibuprofen n = 67 | ||
| Receipt of breakthrough acetaminophen | 18 (28) | 26 (39) | 0.2 |
| No. of breakthrough acetaminophen doses per patient, mean ± SD | 0.7 ± 1.3 | 1.2 ± 2 | 0.09‡ |
| Adverse effects | |||
| Any | 45 (69) | 26 (39) | < 0.001 |
| Nausea | 30 (46) | 13 (19) | 0.002 |
| Vomiting | 12 (18) | 3 (4) | 0.01 |
| Drowsiness | 31 (48) | 15 (22) | 0.003 |
| Dizziness | 20 (31) | 4 (6) | < 0.001 |
| Constipation | 9 (14) | 3 (4) | 0.07 |