Table 4:

Relation between sedentary time and time to death, stratified by frailty index

Model^*	FI score; HR (95% CI)
Model^*	≤ 0.1	0.1 < FI ≤ 0.2	0.2 < FI ≤ 0.3	> 0.3
All participants
Sedentary time, per hour, adjusted for age	0.82 (0.69–0.99)	1.08 (0.99–1.18)	1.23 (1.13–1.34)	1.13 (1.07–1.20)
Sedentary time, per hour, fully adjusted^†	0.90 (0.70–1.14)	1.14 (1.01–1.28)	1.31 (1.14–1.50)	1.35 (1.21–1.50)
Model including objectively measured activity, fully adjusted^†
Sedentary time, per hour	0.90 (0.70–1.15)	1.13 (1.00–1.28)	1.27 (1.11–1.46)	1.36 (1.22–1.52)
Objectively measured activity^‡	1.01 (0.42–2.39)	0.92 (0.56–1.52)	0.20 (0.05–0.83)	1.23 (0.59–2.54)
Model including self-reported activity, fully adjusted^†
Sedentary time, per hour	0.90 (0.70–1.14)	1.14 (1.01–1.29)	1.31 (1.14–1.50)	1.34 (1.21–1.49)
Self-reported activity^§	1.01 (0.41–2.49)	1.07 (0.63–1.81)	0.44 (0.19–1.04)	0.50 (0.20–1.24)
Objectively measured activity^‡
Physically inactive participants
Sedentary time, per hour, fully adjusted^†	1.03 (0.77–1.36)	1.16 (1.02–1.33)	1.27 (1.11–1.46)	1.34 (1.19–1.50)
Physically active participants
Sedentary time, per hour, fully adjusted^†	0.84 (0.62–1.12)^¶		2.31 (0.66–8.13)^¶
Self-reported activity^§
Physically inactive participants
Sedentary time, per hour, fully adjusted^†	0.92 (0.69–1.22)	1.16 (1.02–1.33)	1.32 (1.15–1.51)	1.32 (1.19–1.47)
Physically active participants
Sedentary time, per hour, fully adjusted^†	1.03 (0.75–1.41)^¶		Sample size too small

Note: CI = confidence interval, FI = frailty index, HR = hazard ratio.
↵* All Cox regression models were adjusted for age
↵† Also adjusted for sex, race/ethnicity, education, marital status, employment status, smoking, body mass index, accelerometer wear time and study cohort.
↵‡ Meeting the recommended guidelines of 2.5 hours/week of moderate-to-vigorous physical activity.
↵§ Self-reported vigorous physical activity for a period of at least 10 minutes over the past 30 days.
↵¶ Cells merged because of low sample sizes.