Relation between sedentary time and time to death, stratified by physical activity
| Model* | HR (95% CI) |
|---|---|
| All participants | |
| Sedentary time, per hour, adjusted for age | 1.15 (1.11–1.20) |
| Model including frailty and sedentary time × frailty interaction, fully adjusted† | |
| Sedentary time, per hour | 1.19 (1.11–1.27) |
| Frailty, per 0.01 score | 1.03 (1.03–1.04) |
| Sedentary time × frailty interaction | 1.00 (1.00–1.01) |
| Model including frailty, objectively measured activity, and sedentary time × frailty interaction, fully adjusted† | |
| Sedentary time, per hour | 1.18 (1.10–1.26) |
| Frailty, per 0.01 score | 1.03 (1.03–1.04) |
| Sedentary time × frailty interaction | 1.00 (1.00–1.01) |
| Objectively measured activity‡ | 0.80 (0.57–1.12) |
| Model including frailty, self-reported activity, and sedentary time × frailty interaction, fully adjusted† | |
| Sedentary time, per hour | 1.19 (1.11–1.27) |
| Frailty, per 0.01 score | 1.03 (1.03–1.04) |
| Sedentary time × frailty interaction | 1.00 (1.00–1.01) |
| Self-reported activity§ | 0.77 (0.54–1.09) |
| Objectively measured activity‡ | |
| Physically inactive participants | |
| Sedentary time, per hour, adjusted for age | 1.15 (1.11–1.20) |
| Model including frailty and sedentary time × frailty interaction, fully adjusted† | |
| Sedentary time, per hour | 1.20 (1.12–1.29) |
| Frailty, per 0.01 score | 1.03 (1.03–1.04) |
| Sedentary time × frailty interaction | 1.00 (1.00–1.01) |
| Physically active participants | |
| Sedentary time, per hour, adjusted for age | 0.99 (0.84–1.18) |
| Model including frailty and sedentary time × frailty interaction, fully adjusted† | |
| Sedentary time, per hour | 0.98 (0.78–1.24) |
| Frailty, per 0.01 score | 1.06 (1.02–1.10) |
| Sedentary time × frailty interaction | 1.01 (0.99–1.03) |
| Self-reported activity§ | |
| Physically inactive participants | |
| Sedentary time, per hour, adjusted for age | 1.16 (1.11–1.21) |
| Model including frailty and sedentary time × frailty interaction, fully adjusted† | |
| Sedentary time, per hour | 1.21 (1.13–1.29) |
| Frailty, per 0.01 score | 1.04 (1.03–1.04) |
| Sedentary time × frailty interaction | 1.00 (1.00–1.01) |
| Physically active participants | |
| Sedentary time, per hour, adjusted for age | 0.93 (0.77–1.14) |
| Model including frailty and sedentary time × frailty interaction, fully adjusted† | |
| Sedentary time, per hour | 0.85 (0.64–1.15) |
| Frailty, per 0.01 score | 1.04 (1.00–1.07) |
| Sedentary time × frailty interaction | 0.99 (0.97–1.01) |
Note: CI = confidence interval, HR = hazard ratio.
↵* All Cox regression models were adjusted for age.
↵† Model also adjusted for sex, race/ethnicity, education, marital status, employment status, smoking, body mass index, time wearing accelerometer and study cohort.
↵‡ Meeting the recommended guidelines of 2.5 hours/week of moderate-to-vigorous physical activity.
↵§ Self-reported vigorous physical activity for a period of at least 10 minutes over the past 30 days.