Table 2:

Conversion ratios for opioids

Opioids*To convert to oral morphine equivalent, multiply by:To convert from oral morphine, multiply by:50 mg morphine equivalent dose, mg/d90 mg morphine equivalent dose, mg/d
Codeine0.1–0.26.67334600
Hydromorphone5.00.21018
Morphine1.01.05090
Oxycodone1.50.6673360
Tapentadol0.3–0.43.33160300
Tramadol0.1–0.26.0300540
  • * Conversion ratios for opioids are subject to variations in kinetics governed by genetics and other drugs.

  • The maximum recommended daily dose of tramadol is 300 mg to 400 mg, depending on the formulation.

  • Source: Modified from Nielsen and colleagues.52