Association of highest versus lowest tertile of inflammatory biomarkers with all-cause, cardiovascular and cancer-related mortality over mean follow-up of 16.7 years
| Model; outcome | No. of participants* | No. of deaths* | Biomarker; HR (95% CI) | ||
|---|---|---|---|---|---|
| AGP | IL-6 | CRP | |||
| Model 1† | |||||
| All-cause mortality | 6545 | 736 | 1.43 (1.20–1.65) | 1.93 (1.58–2.37) | 1.52 (1.27–1.83) |
| Cardiovascular mortality | 6541¶ | 181 | 1.64 (1.11–2.43) | 1.96 (1.29–2.99) | 2.00 (1.35–2.97) |
| Cancer-related mortality | 6541¶ | 347 | 1.22 (0.94–1.59) | 1.56 (1.18–2.08) | 1.54 (1.18–2.02) |
| Model 2‡ | |||||
| All-cause mortality | 6545 | 736 | 1.12 (0.92–1.37) | 1.58 (1.27–1.96) | 1.22 (0.99–1.49) |
| Cardiovascular mortality | 6541¶ | 181 | 1.08 (0.71–1.63) | 1.36 (0.86–2.14) | 1.36 (0.88–2.10) |
| Cancer-related mortality | 6541¶ | 347 | 0.96 (0.72–1.27) | 1.28 (0.94–1.73) | 1.29 (0.96–1.73) |
| Model 3§ | |||||
| All-cause mortality | 6545 | 736 | 1.01 (0.82–1.26) | 1.53 (1.21–1.93) | 1.04 (0.83–1.32) |
| Cardiovascular mortality | 6541¶ | 181 | 0.94 (0.60–1.47) | 1.23 (0.76–2.02) | 1.27 (0.78–2.08) |
| Cancer-related mortality | 6541¶ | 347 | 0.85 (0.62–1.15) | 1.19 (0.86–1.65) | 1.29 (0.92–1.81) |
Note: AGP = α-1-acid glycoprotein, CI = confidence interval, CRP = C-reactive protein, HR = hazard ratio, IL-6 = interleukin-6.
↵* Numbers of participants and deaths included in the analysis, including those in the middle tertile.
↵† Adjusted for age and sex.
↵‡ Adjusted for all covariates (age, sex, socioeconomic status, body mass index, health behaviours and chronic disease).
↵§ Adjusted for all covariates and other inflammatory biomarkers.
↵¶ Four participants with unknown cause of death were excluded from these analyses.